Results 101 to 110 of about 35,809 (217)

Evaluation of Novel Isatin–Schiff Base Derivatives: Monoamine Oxidase Inhibition and Antimicrobial Assessment

open access: yesChemMedChem, Volume 21, Issue 16, 27 August 2026.
Five novel series of isatin–Schiff base derivatives are synthesized and evaluated for neuroprotective and anti‐infective potential. The compounds demonstrate exceptional, reversible, and competitive monoamine oxidase inhibition, with chloro‐substitutions dictating isoform selectivity.
Marthinus J. Jooste   +4 more
wiley   +1 more source

Assessing Vancomycin‐Formyl Peptide Conjugate Binding to the Surface of Resistant Staphylococcus aureus via Flow Cytometry

open access: yesChemBioChem, Volume 27, Issue 15, 14 August 2026.
A flow cytometry technique was developed to measure the binding of vancomycin‐formyl peptide conjugates to the surface of resistant Staphylococcus aureus. Binding results indicate that the labelling site of the vancomycin targeting element has a major effect on binding to the bacterial cell wall, which correlates with reduced antibiotic activity ...
Winfrey P. Y. Hoo   +9 more
wiley   +1 more source

Assessment of lactic acid bacteria isolated from traditional Muş Tulum cheese

open access: yesMljekarstvo
The dominant lactic acid bacteria (LAB) population in traditional Muş Tulum cheese, which is produced from unpasteurized sheep’s milk, was identified during the ripening period (on the 1st, 45th, and 90th day) using biochemical, phenotypic, and genotypic
Fatih Rençber   +2 more
doaj   +1 more source

Actinomycin Derivatives: Structural Diversification and Biological Activities

open access: yesChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

Chemical Optimization of Temporin A–L Peptides: From Native Isoforms to Enhanced Antimicrobial Analogs

open access: yesChemMedChem, Volume 21, Issue 15, 14 August 2026.
Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino   +2 more
wiley   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

open access: yesAdvanced Science, Volume 13, Issue 44, 7 August 2026.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott   +5 more
wiley   +1 more source

In vitro adherence of Enterococcus faecalis and Enterococcus faecium to plastic biomaterials [PDF]

open access: yesClinical Microbiology and Infection, 1999
Joyanes, Providencia   +4 more
openaire   +2 more sources

Enterococci-related healthcare-associated ventriculitis and meningitis: a multicenter retrospective case series from clinical practice

open access: yesBMC Neurology
Summary Healthcare-associated ventriculitis and meningitis (HCAVM) is a severe infection and is associated with high morbidity, mortality, and poor functional prognosis, and the associated microorganisms can be skin flora or nosocomial pathogens, most ...
Yuyang Qiu   +8 more
doaj   +1 more source

Structural Modifications of Nonsteroidal Anti‐Inflammatory Drugs (NSAIDs): New Horizons in Antimicrobial Drug Discovery

open access: yesArchiv der Pharmazie, Volume 359, Issue 8, August 2026.
This review provides a comprehensive analysis of the molecular modifications applied to NSAIDs to develop novel antimicrobial agents. By focusing on structural changes and their impact on biological activity, the study highlights innovative strategies to combat the global challenge of antimicrobial resistance.
Ebru Koçak Aslan   +2 more
wiley   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2723-2740, August 2026.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga   +20 more
wiley   +1 more source

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