Results 21 to 30 of about 4,441,967 (229)
Enteroendocrine cells in gastrointestinal pathophysiology
Current Opinion in Pharmacology, 2013 Enteroendocrine cells in the gastrointestinal tract play an important role in the regulation of appetite and digestive responses through the secretion of peptides. Their involvement in gastrointestinal diseases has been acknowledged, but relatively few studies have sought to clearly define their role in the pathogenesis or as therapeutic targets ...
Harrison, Elizabeth +2 more
openaire +4 more sources
The enteroendocrine “letter cells” – time for a new nomenclature?
Scandinavian Journal of Gastroenterology, 2011 Abstract The endocrine cells of the gastrointestinal (GI) tract and the pancreas, referred to as the enteroendocrine cells, secrete a large variety of peptides and amines that regulate functions of the digestive tract itself and of distant organs.
Herbert F, Helander, Lars, Fändriks
openaire +3 more sources
Enteroendocrine cells regulate intestinal barrier permeability. [PDF]
Am J Physiol Cell PhysiolABSTRACT The intestinal epithelial barrier is essential for nutrient absorption and protection against ingested pathogens and foreign substances. Barrier integrity is maintained by tight junctions which are sensitive to inflammatory signals, thus creating a feed-forward loop with an increasingly permeable barrier that further drives ...
Nwako JG +6 more
europepmc +4 more sources
Frontiers in Cellular and Infection Microbiology, 2021 IntroductionInteractions between the gut microbiota and enteroendocrine cells play important role in irritable bowel syndrome (IBS). Reduced stem cell densities and their differentiation into enteroendocrine cells may cause abnormal densities of the ...
Tarek Mazzawi +11 more
doaj +1 more source
Diet: Friend or Foe of Enteroendocrine Cells: How It Interacts with Enteroendocrine Cells [PDF]
Advances in Nutrition, 2012 Gut hormones play a key role in the regulation of food intake, energy expenditure, glucose homeostasis, lipid metabolism, and a wide range of metabolic functions in response to food ingestion. These hormones are altered in metabolic diseases, such as obesity and type 2 diabetes, and are thus proposed to be possible targets for the prevention or ...
Sofia, Moran-Ramos +2 more
openaire +2 more sources
Frontiers in Endocrinology, 2023 The gastrointestinal tract hosts the largest ecosystem of microorganisms in the body. The metabolism of ingested nutrients by gut bacteria produces novel chemical mediators that can influence chemosensory cells lining the gastrointestinal tract ...
Karly E. Masse, Van B. Lu
doaj +1 more source
Pharmacology and physiology of gastrointestinal enteroendocrine cells [PDF]
Pharmacology Research & Perspectives, 2015 AbstractGastrointestinal (GI) polypeptides are secreted from enteroendocrine cells (EECs). Recent technical advances and the identification of endogenous and synthetic ligands have enabled exploration of the pharmacology and physiology of EECs. Enteroendocrine signaling pathways stimulating hormone secretion involve multiple nutrient transporters and G
Mace, O J, Tehan, B, Marshall, F
openaire +2 more sources
Nutrition and L and K-enteroendocrine cells [PDF]
Current Opinion in Endocrinology, Diabetes & Obesity, 2011 The review highlights the influence of nutrients over the secretion of several hormones produced by enteroendocrine cells in the gastrointestinal tract that secrete incretin hormones. These hormones influence glucose homeostasis; food intake; gastric, pancreatic and hepatic secretions; and gastric and intestinal motility, and these aspects are ...
Ruth, Gutierrez-Aguilar +1 more
openaire +2 more sources
Enteroendocrine Dynamics – New Tools Reveal Hormonal Plasticity in the Gut [PDF]
, 2020 The recent intersection of enteroendocrine cell biology with single-cell technologies and novel in vitro model systems has generated a tremendous amount of new data. Here we highlight these recent developments and explore how these findings contribute to
Gehart, Helmuth +2 more
core +1 more source
Enteroendocrine cell regulation of the gut-brain axis
Frontiers in Neuroscience, 2023 Enteroendocrine cells (EECs) are an essential interface between the gut and brain that communicate signals about nutrients, pain, and even information from our microbiome. EECs are hormone-producing cells expressed throughout the gastrointestinal epithelium and have been leveraged by pharmaceuticals like semaglutide (Ozempic, Wegovy), terzepatide ...
Joshua R. Barton +6 more
openaire +3 more sources