Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells. [PDF]
PLoS ONE, 2016 In addition to the T2R bitter taste receptors, neuronal nicotinic acetylcholine receptors (nAChRs) have recently been shown to be involved in the bitter taste transduction of nicotine, acetylcholine and ethanol.
Jie Qian +6 more
doaj +1 more source
An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy.
PLoS ONE, 2014 The enteroendocrine cell is the cornerstone of gastrointestinal chemosensation. In the intestine and colon, this cell is stimulated by nutrients, tastants that elicit the perception of flavor, and bacterial by-products; and in response, the cell secretes
Diego V Bohórquez +5 more
doaj +1 more source
Physiological Reports, 2022 The morphology of the small intestinal mucosa is reflected by the degree of stimuli. Previous studies have come to different conclusion about whether the mucosa is equally symmetrical.
Anna Casselbrant, Herbert F. Helander
doaj +1 more source
Involvement of Intestinal Enteroendocrine Cells in Neurological and Psychiatric Disorders. [PDF]
Biomedicines, 2022 Neurological and psychiatric patients have increased dramatically in number in the past few decades. However, effective treatments for these diseases and disorders are limited due to heterogeneous and unclear pathogenic mechanisms. Therefore, further exploration of the biological aspects of the disease, and the identification of novel targets to ...
Yu L, Li Y.
europepmc +4 more sources
Enteroendocrine cells support intestinal stem-cell-mediated homeostasis in Drosophila [PDF]
, 2019 Intestinal stem cells in the adult Drosophila midgut are regulated by growth factors produced from the surrounding niche cells including enterocytes and visceral muscle.
Ip, Y. Tony +7 more
core +1 more source
Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity [PDF]
, 2018 The intestinal epithelium must balance efficient absorption of nutrients with partitioning commensals and pathogens from the bodies’ largest immune system.
Worthington, John Joseph +2 more
core +4 more sources
Expression of the Bitter Taste Receptor, T2R38, in Enteroendocrine Cells of the Colonic Mucosa of Overweight/Obese vs. Lean Subjects. [PDF]
PLoS ONE, 2016 Bitter taste receptors (T2Rs) are expressed in the mammalian gastrointestinal mucosa. In the mouse colon, T2R138 is localized to enteroendocrine cells and is upregulated by long-term high fat diet that induces obesity. The aims of this study were to test
Rocco Latorre +9 more
doaj +1 more source
Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells. [PDF]
, 2015 Satiety and other core physiological functions are modulated by sensory signals arising from the surface of the gut. Luminal nutrients and bacteria stimulate epithelial biosensors called enteroendocrine cells.
Alex M. Kreger +15 more
core +1 more source
Serotonin production of the developing gastrointestinal tract of human embryos in 6th gestation week [PDF]
Pharmacia, 2023 Background: Local regulation of gastrointestinal tract digestion is performed by a large number of hormones produced by the mucosal enteroendocrine cells. Some of the earliest differentiating cells in the gastrointestinal tract are enteroendocrine cells.
Nadya Penkova +5 more
doaj +3 more sources
Microbial regulation of GLP-1 and L-cell biology
Molecular Metabolism, 2016 Background: The gut microbiota is associated with several of metabolic diseases, including obesity and type 2 diabetes and affects host physiology through distinct mechanisms.
Thomas U. Greiner, Fredrik Bäckhed
doaj +1 more source