Results 41 to 50 of about 4,441,967 (229)

Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing [PDF]

Current Opinion in Endocrinology, Diabetes & Obesity, 2008
This review discusses the role of enteroendocrine cells of the gastrointestinal tract as chemoreceptors that sense lumen contents and induce changes in gastrointestinal function and food intake through the release of signaling substances acting on a variety of targets locally or at a distance.Recent evidence supports the concept that chemosensing in ...
Catia, Sternini, Laura, Anselmi, Enrique, Rozengurt   +2 more
openaire   +2 more sources

Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production

Molecular Metabolism, 2019
Objective: Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy uptake and storage.
Julie Piccand, Constance Vagne, Florence Blot, Aline Meunier, Anthony Beucher, Perrine Strasser, Mari L. Lund, Sabitri Ghimire, Laure Nivlet, Céline Lapp, Natalia Petersen, Maja S. Engelstoft, Christelle Thibault-Carpentier, Céline Keime, Sara Jimenez Correa, Valérie Schreiber, Nacho Molina, Thue W. Schwartz, Adèle De Arcangelis, Gérard Gradwohl   +19 more
doaj   +1 more source

Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion [PDF]

, 2019
Cycling intestinal Lgr5(+) stem cells are intermingled with their terminally differentiated Paneth cell daughters at crypt bottoms. Paneth cells provide multiple secreted (e.g., Wnt, EGF) as well as surface-bound (Notch ligand) niche signals.
van den Born, Maaike, Peters, Peter J.; id_orcid, Clevers, Hans, Van De Wetering, Marc, van Oudenaarden, Alexander, Sasaki, Nobuo, van Es, Johan H., Zeinstra, Laura, Peters, Peter J., Korving, Jeroen, de Wetering, Marc van, Lopez-Iglesias, Carmen, Wiebrands, Kay   +12 more
core   +1 more source

Enteroendocrine cells and appetite dysregulation in Crohn's disease [PDF]

Gut, 2011
Introduction Loss of appetite and malnutrition in active Crohn's disease (CD) are important problems. The biological mechanisms underpinning appetite loss are unclear. Enteroendocrine cells (EEC) form a pivotal part of the brain-gut axis that controls appetite and satiety.
Gordon W. Moran, John McLaughlin
openaire   +1 more source

Somatostatin as an Active Substance of Enteroendocrine Cells in the Canine Digestive Tract in Physiological Conditions and during Inflammatory Bowel Disease

European Journal of Inflammation, 2013
The aim of the present investigation is to examine the changes in the number of somatostatin-like immunoreactive (SOM-LI) enteroendocrine cells in various parts of the canine gastrointestinal (GI) tract during canine inflammatory bowel disease (IBD). The
S. Gonkowski, A. Rychlik, J. Calka
doaj   +1 more source

Duodenal chemosensory system: enterocytes, enteroendocrine cells, and tuft cells. [PDF]

Curr Opin Gastroenterol, 2020
Purpose of review The gut barrier serves as the primary interface between the environment and host in terms of surface area and complexity. Luminal chemosensing is a term used to describe how small molecules in the gut lumen interact with the host through surface receptors or via transport into the subepithelial space.
Akiba Y, Hashimoto S, Kaunitz JD.
europepmc   +6 more sources

Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells [PDF]

, 2016
Lgr5+ adult intestinal stem cells are highly proliferative throughout life. Single Lgr5+ stem cells can be cultured into three-dimensional organoids containing all intestinal epithelial cell types at near-normal ratios.
Seno, Hiroshi, Clevers, Hans, Wiebrands, Kay, van Oudenaarden, Alexander, Basak, Onur, Beumer, Joep   +5 more
core   +1 more source

Expression of Transient Receptor Potential Ankyrin 1 and Transient Receptor Potential Vanilloid 1 in the Gut of the Peri-Weaning Pig Is Strongly Dependent on Age and Intestinal Site

Animals, 2020
Transient receptor potential (TRP) channels contribute to sensory transduction in the body, agonized by a variety of stimuli, such as phytochemicals, and they are predominantly distributed in afferent neurons.
Elout Van Liefferinge, Noémie Van Noten, Jeroen Degroote, Gunther Vrolix, Mario Van Poucke, Luc Peelman, Chris Van Ginneken, Eugeni Roura, Joris Michiels   +8 more
doaj   +1 more source

Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2

Molecular Metabolism, 2023
Objective: Free fatty acid receptor 1 (FFAR1) is highly expressed in enteroendocrine cells of the small intestine and pancreatic beta cells, where FFAR1 agonists function as GLP-1 and insulin secretagogues, respectively.
Jacob Emil Petersen, Maria Hauge Pedersen, Oksana Dmytriyeva, Emilie Nellemose, Tulika Arora, Maja Storm Engelstoft, Wesley B. Asher, Jonathan A. Javitch, Thue W. Schwartz, Mette Trauelsen   +9 more
doaj   +1 more source

Epidermal growth factor promotes intestinal secretory cell differentiation in weaning piglets via Wnt/β-catenin signalling

Animal, 2020
Small intestinal epithelium homeostasis involves four principal cell types: enterocytes, goblet, enteroendocrine and Paneth cells. Epidermal growth factor (EGF) has been shown to affect enterocyte differentiation.
L.X. Wang, F. Zhu, J.Z. Li, Y.L. Li, X.Q. Ding, J. Yin, X. Xiong, H.S. Yang   +7 more
doaj   +1 more source