Results 71 to 80 of about 2,925 (189)

Stem cell‐derived enteroid cultures as a tool for dissecting host‐parasite interactions in the small intestinal epithelium. [PDF]

, 2020
Toxoplasma gondii and Cryptosporidium spp. can cause devastating pathological effects in humans and livestock, and in particular to young or immunocompromised individuals.
Akili D, Akili D, Alak JIB, Benavides J, Bjerkås I, Boehnke K, Cardenas D, Chandra L, Christopher J. Stewart, DeCicco RePass MA, Dubey JP, Dutta D, Ellen‐Alana Tiffney, Fei J, Fofanova TY, Francies HE, Hakim MS, Haller O, Hamilton CA, Harp JA, Harp JA, Holly MK, Hosmillo M, Janine L. Coombes, Laurent F, Lea T, Li B, Liesenfeld O, Lisa Luu, Luke J. Johnston, Luu L, Maillot C, Martínez‐Maqueda D, McCann CM, Miller CN, Miriam F. Hares, Noel G, Oliveira BCM, Oppenheim JJ, Panja A, Quan J‐H, Rajan A, Robin J. Flynn, Santamaria MH, Seydel KB, Silva R, Su J, Tarver AP, Urbischek M, Vergauwen H, Zhang D, Zhang Y‐G, Zhu Z   +52 more
core   +1 more source

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source

Distinct Roles of SLC26A3 and CFTR in Surface pH Regulation and Bicarbonate Secretion in Human Intestinal Epithelium

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Background and Aims Colonic bicarbonate secretion is mediated by the chloride/bicarbonate exchanger SLC26A3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Dysfunction of either causes luminal acidosis, altered mucus properties, and inflammation.
Mahdi Amiri, Azam Salari, Ursula Seidler
wiley   +1 more source

Quantitative Assessment of Gut and Vascular Barriers in TTOP, a Cartridge‐Based Bicompartmental Culture Platform

Advanced Materials Technologies, Volume 11, Issue 1, 8 January 2026.
The modular, versatile, and standardized cartridge‐based culture module allows to replicate gut and vascular barriers. Its conventional handling requirements facilitate adoption by non‐technical users, while the design allows safe manipulation and retrieval of samples for permeability assays and endpoint analysis.
Lorenzo Pietro Coppadoro, Maria Lombardi, Sabrina Nicolò, Alessandra Maria Anna Rando, Gianfranco Beniamino Fiore, Chiara Foglieni, Monica Soncini   +6 more
wiley   +1 more source

The norovirus NS3 protein is a dynamic lipid- and microtubule-associated protein involved in viral RNA replication [PDF]

, 2017
Norovirus (NoV) infections are a significant health burden to society, yet the lack of reliable tissue culture systems has hampered the development of appropriate antiviral therapies.
Cotton, Ben T, Green, Kim Y, Hyde, Jennifer L, Mackenzie, Jason M, Sarvestani, Soroush T, Sosnovtsev, Stanislav V, White, Peter A   +6 more
core   +2 more sources

The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair [PDF]

, 2015
In this study we characterized the effects of radiation injury on the expression and function of the autotaxin (ATX)-LPA2 GPCR axis. In IEC-6 crypt cells and jejunum enteroids quantitative RT-PCR showed a time- and dose-dependent upregulation of lpa2 in ...
Balazs, Louisa, Balogh, Andrea, Banerje, Souvik, Bavaria, Mitul, Gangwar, Ruchika, Lee, Sue Chin, Miller, Duane D., Moon, ChangSuk, Naren, Anjaparavanda P., Norman, Derek D., Pelus, Louis, Rao, Radakrishna, Ray, Ramesh, Shimizu, Yoshibumi, Shukla, Pradeep, Tigyi, Gabor   +15 more
core   +1 more source

Natural Products as Potential Resource Library for Control of Major Swine Enteric Viruses

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Major swine enteric viruses (SEVs), including porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), swine acute diarrhea syndrome coronavirus (SADS‐CoV), and porcine rotavirus (PoRV), cause severe gastrointestinal diseases in pigs, leading to huge economic losses to the swine industry ...
Jialu Zhang, Yuqian Liu, Shuying Ren, Zhouyuan Wang, Yunxia Li, Lianci Peng, Rendong Fang, Jianchao Wei   +7 more
wiley   +1 more source

Cytokine tuning of intestinal epithelial function [PDF]

, 2018
The intestine serves as both our largest single barrier to the external environment and the host of more immune cells than any other location in our bodies.
Andrews, Caroline, Durum, Scott K., McLean, Mairi H.   +2 more
core   +4 more sources

Porcine colonoids and enteroids keep the memory of their origin during regeneration [PDF]

, 2021
The development of alternative in vitro culture methods has increased in the last decade as three-dimensional organoids of various tissues, including those of the small and large intestines.
Barnett AM, Hendriks C, Le Borgne L, McNabb WC, Mullaney JA, Roy NC   +5 more
core   +2 more sources

Immune and Immune‐Integrated Organoids as NextGeneration Platforms for Disease Modeling

MedComm, Volume 6, Issue 12, December 2025.
This graphical abstract outlines the sources and methods for integrating immune cells into organoids. Immune cells can be derived from peripheral blood, tissues, or differentiated from human‐induced pluripotent stem cells. The immune cells are incorporated into the organoid by using coculture techniques, direct injection, as well as scaffolds and air ...
Kimiya Rashidan, Malaksima Ayadilord, Ali Hazrati, Amirhossein Nazerian, Abbas Shafiee, Seyed Mahmoud Hashemi   +5 more
wiley   +1 more source