Results 51 to 60 of about 2,029 (168)
Reviews in Medical Virology, Volume 35, Issue 6, November 2025.ABSTRACT Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency, characterised by impaired antibody production, immune dysregulation, and a broad spectrum of clinical manifestations. Gastrointestinal involvement is frequent, affecting up to 20% of patients and significantly contributing to morbidity and ...
Györgyi Műzes, Ferenc Sipos
wiley +1 more source
Insights into human norovirus cultivation in human intestinal enteroids
mSphereABSTRACT Human noroviruses (HuNoVs) are a significant cause of epidemic and sporadic acute gastroenteritis worldwide. The lack of a reproducible culture system hindered the study of HuNoV replication and pathogenesis for almost a half-century.
Khalil Ettayebi +15 more
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Ex Vivo Enteroids Recapitulate In Vivo Citrulline Production in Mice [PDF]
The Journal of Nutrition, 2018 The endogenous production of arginine relies on the synthesis of citrulline by enteral ornithine transcarbamylase (OTC). Mutations in the gene coding for this enzyme are the most frequent cause of urea cycle disorders. There is a lack of correlation between in vivo metabolic function and DNA sequence, transcript abundance, or in vitro enzyme activity ...
Xiaoying Wang +4 more
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, 2017 Scientific Reports 7: Article number: 45270; published online: 27 March 2017; updated: 03 May 2017 The previous PDF version of this Article contained a typographical error in the Results section under the subheading ‘Generation of mature human ...
Nicholas C. Zachos +6 more
core +1 more source
Generation of a canine enteroid-derived monolayer model to study gut barrier structure and function [PDF]
, 2022 Conventional in-vitro models of intestinal epithelium such as human intestinal/colonic cancer cell lines lack essential features of the canine intestine, limiting their use to study canine intestinal barrier function, cellular metabolism, or host-microbe
Lopez Cervantes, Veronica Martina
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iMeta, Volume 4, Issue 5, October 2025.Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang +12 more
wiley +1 more source
, 2019 When transmitted through the oral route, Toxoplasma gondii first interacts with its host at the small intestinal epithelium. This interaction is crucial to controlling initial invasion and replication, as well as shaping the quality of the systemic ...
Janine L. Coombes (7319504) +9 more
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, 2022 Differentiated ileal enteroid monolayers (35I) were exposed to different concentrations of purified ST toxin for 8 hrs (A) or infected with wildtype strains H10407 or CVD30 from 90 min to 8 hrs (B).
Emily M. Smith (1326564) +4 more
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Advanced Science, Volume 12, Issue 36, September 25, 2025.An integral functional axis through which GPN and functional metabolites of Alistipes senegalensis can hydrolyze tryptophan into indoles. Furthermore, the Alistipes senegalensis‐indole‐AhR pathway is found to be associated with increased expression of tight junction‐associated proteins and activation of gut stem cells.
Dandan Wang +10 more
wiley +1 more source
Enteroid culture and its impact on stem cell and cancer research
, 2014 The technique of enteroid cell culture has had an enormous effect on the study of intestinal stem cells as well as colorectal cancer, and will continue to aid scientists in making advances in these fields in the future.
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