Results 81 to 90 of about 2,925 (189)

Bifidobacterium longum alleviates irritable bowel syndrome-related visceral hypersensitivity and microbiota dysbiosis via Paneth cell regulation

Gut Microbes, 2020
Although the oral administration of Bifidobacterium longum (B. longum) relieves the signs of irritable bowel syndrome (IBS) in clinical settings, the mechanisms underlying its effects are unclear.
Chunhua Zhou, Xue Fang, Jiajia Xu, Jun Gao, Ling Zhang, Jiulong Zhao, Yuting Meng, Wei Zhou, Xu Han, Yu Bai, Zhaoshen Li, Duowu Zou   +11 more
doaj   +1 more source

Generation of Intestinal and Colonic Organoids Derived From Human Pluripotent Stem Cells

Biology of the Cell, Volume 117, Issue 12, December 2025.
Human pluripotent stem cells can be guided through a stepwise differentiation process to produce self‐organizing intestinal and colonic organoids. The resulting organoids recapitulate fetal‐stage epithelial and mesenchymal organization, offering a powerful model to explore human gastrointestinal development and its disorders.
Lola Bonneau, Lisa Brossard, Theo Noël, Victor Perreaux, Laura Bachir, Archie Khan, Simon Vales, Maxime M. Mahe   +7 more
wiley   +1 more source

Initial pig developmental stage influences intestinal organoid growth but not cellular composition

Animal Models and Experimental Medicine
Background Intestinal organoids are promising tools in the context of animal experiment reduction but a thorough characterization of the impact of the origin of intestinal stem cells (ISC) on organoid phenotype is needed to routinely use this cellular ...
Camille Duchesne, Gwénaëlle Randuineau, Laurence Le Normand, Véronique Romé, Samia Laraqui, Alexis Pierre Arnaud, Gaëlle Boudry   +6 more
doaj   +1 more source

CVID Enteropathy Associated With Chronic Norovirus Infection: Background, Clinical Features, and Therapeutic Aspects

Reviews in Medical Virology, Volume 35, Issue 6, November 2025.
ABSTRACT Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency, characterised by impaired antibody production, immune dysregulation, and a broad spectrum of clinical manifestations. Gastrointestinal involvement is frequent, affecting up to 20% of patients and significantly contributing to morbidity and ...
Györgyi Műzes, Ferenc Sipos
wiley   +1 more source

Enteroendocrine Progenitor Cell–Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent MannerSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: The enteroendocrine cell (EEC) lineage is important for intestinal homeostasis. It was recently shown that EEC progenitors contribute to intestinal epithelial growth and renewal, but the underlying mechanisms remain poorly understood ...
Ajeet P. Singh, Yu-Han Hung, Michael T. Shanahan, Matt Kanke, Alessandro Bonfini, Michael K. Dame, Mandy Biraud, Bailey C.E. Peck, Oyebola O. Oyesola, John M. Freund, Rebecca L. Cubitt, Ennessa G. Curry, Liara M. Gonzalez, Gavin A. Bewick, Elia D. Tait-Wojno, Natasza A. Kurpios, Shengli Ding, Jason R. Spence, Christopher M. Dekaney, Nicolas Buchon, Praveen Sethupathy   +20 more
doaj   +1 more source

Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro. [PDF]

, 2018
Human norovirus (HuNoV) is a major cause of nonbacterial gastroenteritis worldwide, yet despite its impact on society, vaccines and antivirals are currently lacking. A HuNoV replicon system has been widely applied to the evaluation of antiviral compounds
Emmott, Edward, Goodfellow, Ian, Hosmillo, Myra, Kitano, Mitsutaka, Lu, Jia   +4 more
core   +1 more source

Organoid-based in vitro system and reporter for the study of Cryptosporidium parvum sexual reproduction

Microbiology Spectrum
Many advances have been made recently in our understanding of Cryptosporidium’s asexual cycle and sexual differentiation. However, the process of fertilization, which is required for transmission of infectious oocysts, is not well understood.
Bethany R. Korwin-Mihavics, Emmett A. Dews, Peter Miller, Alexandra Cameron, Bruno Martorelli di Genova, Christopher D. Huston   +5 more
doaj   +1 more source

Synchronous enteroid adenocarcinoma at the ureteral implantation site after ureterosigmoidostomy

Urology Case Reports, 2022
Ureterosigmoidostomy is considered to be the oldest urinary diversion technique performed for the first time in the 19th Century in patients with urinary malformations. However, the high rate of complications as well as the significant risk of developing
B. Gómez González, A. Hevia Feliú, D. Serralta de Colsa, S. Salinas Moreno, I. González-Valcarcel de Torres, J.M. De la Morena Gallego   +5 more
doaj   +1 more source

Organoids as a Model for Intestinal Ion Transport Physiology [PDF]

, 2020
The advent of intestinal organoid culture in 2009 was a fortuitous development in the search for a valid marker of intestinal stem cells, and provided proof of murine intestinal stem cell regenerative potential.
A Bein, A Elgavish, A Ermund, A Kapus, A Kockerling, A Ootani, A Reynolds, AD Gracz, AM Gallagher, AM Strubberg, B Lee, B van der Hee, BD Ramsey, BLN Than, BM Fihn, C Hofmann, C Vitzthum, CA Bertrand, CA Flores, CE Wainwright, CH Yun, CP Stewart, D-A Hallbäck, DD Zomer-van Ommen, EH Fernando, EV O’Loughlin, FJ Accurso, FS Collins, G Schwank, G Vega, G Wilke, GA Kim, GS Evans, H Barriere, H Cheng, H Miyoshi, H Miyoshi, H Zhao, HGM Heijerman, HJ Kim, HJ Kim, HR De Jonge, I Heo, J Foulke-Abel, J Foulke-Abel, J Linley, J Liu, J Liu, J Yin, JE Matos, JE Simpson, JF Dekkers, JF Dekkers, JG In, JH Chen, JH Poulsen, JK Foskett, JR Spence, JR Thiagarajah, JS Dutton, JS Schwarz, JY Co, K De Boeck, K Kunzelmann, K Kurashima, K Saxena, K Szászi, K Yu, K-A Kim, KE Barrett, KL VanDussen, L Ferrera, LR Avula, LR Gawenis, LW Plasschaert, M Donowitz, M Hirokawa, M Stelzner, M Zizak, MA Ainsworth, MA Engevik, MA Valverde, ME Robert, MJC Bijvelds, MJC Bijvelds, MK Estes, MK Fuller, MP Boyle, MR Dorwart, MW van der Helm, N Barker, N Petersen, NM Walker, O Basak, O Furukawa, O Mignen, PG Middleton, PG Noone, PM Quinton, PT Ikpa, R Benedetto, R Greger, R Greger, RA Gottlieb, RB Bajnath, RJ Lee, RJ MacLeod, RL Jakab, S Eklund, S Middendorp, S Yui, SK Singh, T Matsu-Ura, T Paul, T Sato, T Sato, T Sato, T Tamada, TV Strong, U Seidler, W Namkung, W Shin, X Liu, X Yin, Y Kim, Y Sui, Y Wang, Y Yin, Y Yin, Z Davoudi   +129 more
core   +2 more sources

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

iMeta, Volume 4, Issue 5, October 2025.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang, Bin Wang, Yong‐Le Yang, Jin‐Xin Meng, Meng‐Di Zhang, Yi‐Ke Li, Bo Dong, Yanan Zhang, Bo‐Wen Liu, Dong Yang, Chun‐Miao Ji, Yao‐Wei Huang, Shu Jeffrey Zhu   +12 more
wiley   +1 more source