Results 11 to 20 of about 10,893 (158)

Detection of enterotoxigenic Bacteroides fragilis in patients with ulcerative colitis [PDF]

Gut Pathogens, 2017
Purpose Ulcerative colitis (UC) as a type of inflammatory bowel disease (IBD), presumed to occur as a consequence of increased immune responses to intestinal microbiota in genetically susceptible individuals.
Samin Zamani, Sonia Hesam Shariati, Mohammad Reza Zali, Hamid Asadzadeh Aghdaei, Akram Sarabi Asiabar, Saied Bokaie, Bizhan Nomanpour, Leonardo Antonio Sechi, Mohammad Mehdi Feizabadi   +8 more
doaj   +6 more sources

Enrichment of Bacteroides fragilis and enterotoxigenic Bacteroides fragilis in CpG island methylator phenotype-high colorectal carcinoma. [PDF]

Clin Microbiol Infect
OBJECTIVES Data support that enterotoxigenic Bacteroides fragilis (ETBF) harbouring the Bacteroides fragilis toxin (bft) gene may promote colorectal tumourigenesis through the serrated neoplasia pathway.
Takashima Y, Kawamura H, Okadome K, Ugai S, Haruki K, Arima K, Mima K, Akimoto N, Nowak JA, Giannakis M, Garrett WS, Sears CL, Song M, Ugai T, Ogino S.   +14 more
europepmc   +4 more sources

Antibody response to enterotoxigenic Bacteroides fragilis of Filipino colorectal cancer patients. [PDF]

Asian Biomed (Res Rev News), 2023
Background Several species of the gut microbiota have been implicated in colorectal cancer (CRC) development. The anaerobic bacterium enterotoxigenic Bacteroides fragilis (ETBF), has been identified to produce fragilysin, a toxin known to cleave E ...
Cariño AMD, Balanag GA, Magat EM, Fellizar A, Ortin TS, Villaflores O, Guevarra L, Albano PM.   +7 more
europepmc   +4 more sources

Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia. [PDF]

PLoS ONE, 2017
BackgroundEnterotoxigenic Bacteroides fragilis (ETBF) is a toxin-producing bacteria thought to possibly promote colorectal carcinogenesis by modulating the mucosal immune response and inducing epithelial cell changes.
Rachel V Purcell, John Pearson, Alan Aitchison, Liane Dixon, Frank A Frizelle, Jacqueline I Keenan   +5 more
doaj   +3 more sources

Enterotoxigenic Bacteroides fragilis induces the stemness in colorectal cancer via upregulating histone demethylase JMJD2B [PDF]

Gut Microbes, 2020
The enrichment of Enterotoxigenic Bacteroides fragilis (ETBF) has been identified in CRC patients and associated with worse prognosis. Cancer stem cells (CSCs) play essential roles in CRC development.
Qian-Qian Liu, Chun-Min Li, Lin-Na Fu, Hao-Lian Wang, Juan Tan, Yun-Qian Wang, Dan-Feng Sun, Qin-Yan Gao, Ying-Xuan Chen, Jing-Yuan Fang   +9 more
doaj   +3 more sources

Enterotoxigenic Bacteroides fragilis infection exacerbates tumorigenesis in AOM/DSS mouse model. [PDF]

Int J Med Sci, 2020
The azoxymethane (AOM)/dextran sulfate sodium (DSS) murine model is commonly used to study colitis-associated cancer. The human commensal bacterium, enterotoxigenic Bacteroides fragilis (ETBF) secretes the Bacteroides fragilis toxin (BFT) which is ...
Hwang S, Lee CG, Jo M, Park CO, Gwon SY, Hwang S, Yi HC, Lee SY, Eom YB, Karim B, Rhee KJ.   +10 more
europepmc   +5 more sources

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis. [PDF]

Mucosal Immunol, 2017
Enterotoxigenic Bacteroides fragilis (ETBF), a human commensal and candidate pathogen in colorectal cancer (CRC), is a potent initiator of interleukin-17 (IL-17)-dependent colon tumorigenesis in MinApc+/− mice.
Thiele Orberg E, Fan H, Tam AJ, Dejea CM, Destefano Shields CE, Wu S, Chung L, Finard BB, Wu X, Fathi P, Ganguly S, Fu J, Pardoll DM, Sears CL, Housseau F.   +14 more
europepmc   +5 more sources

Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene. [PDF]

Microbiol Spectr, 2022
Many studies have shown that microbiome composition in both the mucosa and the stool differs in individuals with sporadic and hereditary colorectal cancer (CRC).
Allen J, Rosendahl Huber A, Pleguezuelos-Manzano C, Puschhof J, Wu S, Wu X, Boot C, Saftien A, O'Hagan HM, Wang H, van Boxtel R, Clevers H, Sears CL.   +12 more
europepmc   +2 more sources

Genomic Diversity of Enterotoxigenic Strains of Bacteroides fragilis. [PDF]

PLoS ONE, 2016
Enterotoxigenic (ETBF) strains of Bacteroides fragilis are the subset of strains that secrete a toxin called fragilysin (Bft). Although ETBF strains are known to cause diarrheal disease and have recently been associated with colorectal cancer, they have ...
Jessica V Pierce, Harris D Bernstein
doaj   +4 more sources

Promotion of Colitis in B Cell-Deficient C57BL/6 Mice Infected with Enterotoxigenic Bacteroides fragilis. [PDF]

Int J Mol Sci, 2023
Enterotoxigenic Bacteroides fragilis (ETBF) causes colitis and is implicated in inflammatory bowel diseases and colorectal cancer. The ETBF-secreted B. fragilis toxin (BFT) causes cleavage of the adherence junction, the E-cadherin, resulting in the large
Jo M, Hwang S, Lee CG, Hong JE, Kang DH, Yoo SH, Kim WS, Yoo JY, Rhee KJ.   +8 more
europepmc   +2 more sources