Results 41 to 50 of about 2,879 (160)

Diversity of the Metalloprotease Toxin Produced by Enterotoxigenic Bacteroides fragilis [PDF]

Infection and Immunity, 2002
ABSTRACT Enterotoxigenic Bacteroides fragilis (ETBF) strains produce a 20-kDa zinc metalloprotease toxin (BFT) associated with diarrheal disease of animals, young children, and adults. BFT stimulates secretion in intestinal loops in vivo and modifies epithelial cell morphology in vitro.
Shaoguang, Wu, Lawrence A, Dreyfus, Art O, Tzianabos, Chika, Hayashi, Cynthia L, Sears   +4 more
openaire   +2 more sources

Outer membrane vesicles secreted by Bacteroides fragilis inhibit CFTR chloride secretion by human colon organoids

Infection and Immunity
The goals of this study were to develop a model to study host-pathogen interactions in primary human colon organoids and to test the hypothesis that Bacteroides fragilis toxin (BFT-2) secreted in outer membrane vesicles (OMVs) modulates mucosal immunity ...
Roxanna Barnaby, Amanda Nymon, Paige Salerno, Carolyn T. Roche, Young Ah Goo, Byoung-Kyu Cho, Timothy B. Gardner, Zdenek Svindrych, Douglas J. Taatjes, Thomas H. Hampton, Benjamin Ross, Bruce A. Stanton   +11 more
doaj   +1 more source

Gut microbiome: decision-makers in the microenvironment of colorectal cancer

Frontiers in Cellular and Infection Microbiology, 2023
Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract, accounting for the second most common cause of gastrointestinal tumors. As one of the intestinal barriers, gut bacteria form biofilm, participate in intestinal work, and form ...
Jingrun Han, Biao Zhang, Biao Zhang, Yongnian Zhang, Tianyi Yin, Yuying Cui, Yuying Cui, Yuying Cui, Jinming Liu, Yanfei Yang, Huiyi Song, Huiyi Song, Huiyi Song, Dong Shang, Dong Shang, Dong Shang   +15 more
doaj   +1 more source

In Vitro Evaluation of Propolis Effects on Bacteroides fragilis Toxin-mediated Inflammatory Pathways

Korean Journal of Clinical Laboratory Science
Colorectal cancer (CRC) remains a significant global health concern because of its increasing incidence and mortality rates. Chronic intestinal inflammation is a critical driver in the pathogenesis of CRC, particularly in individuals with inflammatory ...
Soonjae HWANG, Yeram LEE, Ki-Jong RHEE
doaj   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

EnterotoxigenicBacteroides fragilis: a Rogue among Symbiotes [PDF]

Clinical Microbiology Reviews, 2009
SUMMARYEnterotoxigenicBacteroides fragilis(ETBF) strains are strains ofB. fragilisthat secrete a 20-kDa heat-labile zinc-dependent metalloprotease toxin termed theB. fragilistoxin (BFT). BFT is the only recognized virulence factor specific for ETBF. ETBF strains are associated with inflammatory diarrheal disease in children older than 1 year of age and
openaire   +2 more sources

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Effect of gut microbiota in the colorectal cancer and potential target therapy

Discover Oncology, 2022
The symbiotic interaction between gut microbiota and the digestive tract is an important factor in maintaining the intestinal environment balance. Colorectal cancer (CRC) is a complex disease involving the interaction between tumour cells and a large ...
Junchuan Li, Yuzhou Zhu, Lie Yang, Ziqiang Wang   +3 more
doaj   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Diarrheal disease caused by enterotoxigenic Bacteroides fragilis in infant rabbits [PDF]

Journal of Clinical Microbiology, 1989
Enterotoxigenic Bacteroides fragilis caused severe, nonhemorrhagic, watery diarrhea when 10(9) CFU of a porcine or human isolate was administered orogastrically to 3-day-old rabbits. The bacterium colonized the intestinal tract with a predilection for the large intestine (10(9) CFU/g of cecal contents).
L L, Myers, D S, Shoop, J E, Collins, W C, Bradbury   +3 more
openaire   +2 more sources