Screening and Epitope Characterization of Diagnostic Nanobody Against Total and Activated Bacteroides fragilis Toxin [PDF]
Frontiers in Immunology, 2023 Enterotoxigenic Bacteroides fragilis (ETBF) can rapidly secrete an enterotoxin termed B. fragilis toxin (BFT), which is thought to be the only recognized virulence factor in ETBF.
Min Jiao, Yu-rong Wen, Serge Muyldermans
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Purification and Characterization of His-Tagged Recombinant Bacteroides fragilis Toxin-2 Variants In Vitro and In Vivo [PDF]
ToxinsBacteroides fragilis is a major commensal bacterium of the human colon. However, enterotoxigenic B. fragilis (ETBF) secretes B. fragilis toxin (BFT), a zinc-dependent metalloprotease that cleaves E-cadherin and promotes chronic inflammation and ...
Woo-Seung Kim +4 more
doaj +3 more sources
Biological Mechanisms of Enterotoxigenic Bacteroides fragilis Toxin: Linking Inflammation, Colorectal Cancer, and Clinical Implications [PDF]
ToxinsEnterotoxigenic Bacteroides fragilis (ETBF) has emerged as a gut microbiome pathogen that can promote intestinal inflammation and contribute to colorectal cancer (CRC).
Seyedesomaye Jasemi +5 more
doaj +4 more sources
The “Direct Structural Disruption” Hypothesis: Bacteroides fragilis Toxin as a Potentiating Cofactor in MASH Pathogenesis [PDF]
ToxinsMetabolic dysfunction-associated steatohepatitis (MASH) is a complex, multifactorial disease heavily influenced by the gut–liver axis. While enterotoxigenic Bacteroides fragilis (ETBF) and its principal virulence factor, B.
Ju-Eun Hong, Soonjae Hwang
doaj +3 more sources
Bacteroides fragilis Toxin Induces Intestinal Epithelial Cell Secretion of Interleukin-8 by the E-Cadherin/β-Catenin/NF-κB Dependent Pathway [PDF]
Biomedicines, 2022 Enterotoxigenic Bacteroides fragilis (ETBF) has emerged as a gut microbiome pathogen that can promote colitis associated cancer in humans. ETBF secretes the metalloprotease, B.
Chang-Gun Lee +6 more
doaj +2 more sources
Bacteroides fragilis Toxin Induces Sequential Proteolysis of E-Cadherin and Inflammatory Response in Mouse Intestinal Epithelial Cell Line [PDF]
MicroorganismsEnterotoxigenic Bacteroides fragilis (ETBF) is an intestinal bacterium that secretes the metalloprotease Bacteroides fragilis toxin (BFT), which induces E-cadherin cleavage and interleukin-8 secretion in human intestinal epithelial cell lines.
Woo-Seung Kim +10 more
doaj +2 more sources
Outer membrane vesicles secreted by Bacteroides fragilis inhibit CFTR chloride secretion by human colon organoids [PDF]
Infection and ImmunityThe goals of this study were to develop a model to study host-pathogen interactions in primary human colon organoids and to test the hypothesis that Bacteroides fragilis toxin (BFT-2) secreted in outer membrane vesicles (OMVs) modulates mucosal immunity ...
Roxanna Barnaby +11 more
doaj +2 more sources
Nontoxigenic Bacteroides fragilis as a Next-Generation Probiotic: Mechanisms, Safety, and Therapeutic Potential [PDF]
MicroorganismsNontoxigenic Bacteroides fragilis (NTBF) is defined by the absence of the bft gene and corresponding B. fragilis toxin production; however, nontoxigenic status alone does not establish uniform safety or probiotic function.
Dong Wang +11 more
doaj +2 more sources
An ubiquitous antibacterial toxin from human gut bacteria engenders neonatal colonization advantage [PDF]
Nature CommunicationsBacteroides fragilis is a common member of the human colonic microbiota. In children, the B. fragilis Type 6 Secretion System (T6SS) has been suggested to mediate dominance between coexisting strains.
Ezequiel Valguarnera +6 more
doaj +2 more sources
Association of Pre-Diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins With Colorectal Cancer in a European Cohort [PDF]
Gut Microbes, 2021 Alicia K Heath +2 more
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