Results 31 to 40 of about 5,698 (153)

Bacteroides fragilis Enterotoxin Gene Sequences in Patients with Inflammatory Bowel Disease

Emerging Infectious Diseases, 2000
We identified enterotoxigenic Bacteroides fragilis in stool specimens of patients with inflammatory bowel disease and other gastrointestinal disorders. The organism was detected in 11 (13.2%) of 83 patients with inflammatory bowel disease. Of 57 patients
Thomas P. Prindiville, Rafik A. Sheikh, Stuart H. Cohen, Yajarayma J. Tang, Mary C. Cantrell, Joseph Silva   +5 more
doaj   +1 more source

Enterotoxigenic Bacteroides fragilis: A Possible Etiological Candidate for Bacterially-Induced Colorectal Precancerous and Cancerous Lesions

Frontiers in Cellular and Infection Microbiology, 2020
Enterotoxigenic Bacteroides fragilis (ETBF) produces Bacteroides fragilis toxin (BFT), which is associated with acute diarrheal, inflammatory bowel disease, and colorectal cancer (CRC).
Samin Zamani, Samin Zamani, Reza Taslimi, Akram Sarabi, Seyedesomaye Jasemi, Leonardo A. Sechi, Mohammad Mehdi Feizabadi, Mohammad Mehdi Feizabadi   +7 more
doaj   +1 more source

Antibiotic resistance pattern of Bacteroides fragilis isolated from clinical and colorectal specimens

Annals of Clinical Microbiology and Antimicrobials, 2021
Background Bacteroides fragilis is a part of the normal gastrointestinal flora, but it is also the most common anaerobic bacteria causing the infection. It is highly resistant to antibiotics and contains abundant antibiotic resistance mechanisms. Methods
Seyedesomaye Jasemi, Mohammad Emaneini, Zahra Ahmadinejad, Mohammad Sadegh Fazeli, Leonardo A. Sechi, Fatemah Sadeghpour Heravi, Mohammad Mehdi Feizabadi   +6 more
doaj   +1 more source

Gut microbiome: decision-makers in the microenvironment of colorectal cancer

Frontiers in Cellular and Infection Microbiology, 2023
Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract, accounting for the second most common cause of gastrointestinal tumors. As one of the intestinal barriers, gut bacteria form biofilm, participate in intestinal work, and form ...
Jingrun Han, Biao Zhang, Biao Zhang, Yongnian Zhang, Tianyi Yin, Yuying Cui, Yuying Cui, Yuying Cui, Jinming Liu, Yanfei Yang, Huiyi Song, Huiyi Song, Huiyi Song, Dong Shang, Dong Shang, Dong Shang   +15 more
doaj   +1 more source

Gut Symbiont Bacteroides fragilis Secretes a Eukaryotic-Like Ubiquitin Protein That Mediates Intraspecies Antagonism

mBio, 2017
Human gut Bacteroides species produce different types of toxins that antagonize closely related members of the gut microbiota. Some are toxic effectors delivered by type VI secretion systems, and others are non-contact-dependent secreted antimicrobial ...
Maria Chatzidaki-Livanis, Michael J. Coyne, Kevin G. Roelofs, Rahul R. Gentyala, Jarreth M. Caldwell, Laurie E. Comstock   +5 more
doaj   +1 more source

Bacteroides fragilis toxin expression enables lamina propria niche acquisition in the developing mouse gut. [PDF]

Nat Microbiol
Bacterial toxins are well-studied virulence factors; however, recent studies have revealed their importance in bacterial niche adaptation. Enterotoxigenic Bacteroides fragilis (ETBF) expresses B. fragilis toxin (BFT) that we hypothesized may contribute to both colonic epithelial injury and niche acquisition.
Hill CA, Casterline BW, Valguarnera E, Hecht AL, Shepherd ES, Sonnenburg JL, Bubeck Wardenburg J.   +6 more
europepmc   +3 more sources

Bacteroides fragilis toxin 2 damages human colonic mucosa in vitro [PDF]

Gut, 1999
BACKGROUND Strains of Bacteroides fragilis producing a 20 kDa protein toxin ( B fragilis toxin (BFT) or fragilysin) are associated with diarrhoea in animals and humans.
M, Riegler, M, Lotz, C, Sears, C, Pothoulakis, I, Castagliuolo, C C, Wang, R, Sedivy, T, Sogukoglu, E, Cosentini, G, Bischof, W, Feil, B, Teleky, G, Hamilton, J T, LaMont, E, Wenzl   +14 more
openaire   +2 more sources

The Bacteroides fragilis Toxin Binds to a Specific Intestinal Epithelial Cell Receptor [PDF]

Infection and Immunity, 2006
ABSTRACT The Bacteroides fragilis toxin (BFT) is the only known virulence factor of enterotoxigenic B. fragilis . BFT has previously been shown to act, at least in part, through cleavage of the intercellular adhesion protein E-cadherin.
Shaoguang, Wu, Jai, Shin, Guangming, Zhang, Mitchell, Cohen, Augusto, Franco, Cynthia L, Sears   +5 more
openaire   +2 more sources

Distinct interactions with cellular E-cadherin of the two virulent metalloproteinases encoded by a Bacteroides fragilis pathogenicity island. [PDF]

PLoS ONE, 2014
Bacteroides fragilis causes the majority of Gram-negative anaerobic infections in the humans. The presence of a short, 6-kb, pathogenicity island in the genome is linked to enterotoxigenic B. fragilis (ETBF). The role of the enterotoxin in B.
Albert G Remacle, Sergey A Shiryaev, Alex Y Strongin   +2 more
doaj   +1 more source

Monoclonal antibodies specific for Bacteroides fragilis enterotoxins BFT1 and BFT2 and their use in immunoassays. [PDF]

PLoS ONE, 2017
We have developed 22 mouse IgG1 monoclonal antibodies (mAbs) against Bacteroides fragilis zinc metalloprotease toxins 1 and 2 (BFT1 and BFT2). Mice were immunized with recombinant BFT1 or BFT2 proteins with metalloprotease activity.
Saraspadee Mootien, Paul M Kaplan
doaj   +1 more source