Results 41 to 50 of about 5,698 (153)

Enterotoxigenic Bacteroides fragilis activates IL-8 expression through Stat3 in colorectal cancer cells

Gut Pathogens, 2022
Background Enterotoxigenic Bacteroides fragilis (ETBF) has been implicated in colorectal carcinogenesis through the actions of its toxin, B. fragilis toxin (BFT).
Rachel V. Purcell, Jessica Permain, Jacqueline I. Keenan   +2 more
doaj   +1 more source

A systemic review of the role of enterotoxic Bacteroides fragilis in colorectal cancer

Neoplasia: An International Journal for Oncology Research, 2022
Enterotoxigenic Bacteroides fragilis (ETBF) has received significant attention for a possible association with, or causal role in, colorectal cancer (CRC).
Nancy Scott, Emma Whittle, Patricio Jeraldo, Nicholas Chia   +3 more
doaj   +1 more source

The C-Terminal Region of Bacteroides fragilis Toxin Is Essential to Its Biological Activity [PDF]

Infection and Immunity, 2006
ABSTRACT To evaluate the role of the C-terminal region in Bacteroides fragilis toxin (BFT) activity, processing, and secretion, sequential C-terminal truncation and point mutations were created by site-directed mutagenesis.
Cynthia L, Sears, Simy L, Buckwold, Jai W, Shin, Augusto A, Franco   +3 more
openaire   +2 more sources

Intestinal phages interact with bacteria and are involved in human diseases

Gut Microbes, 2022
Phages are the most abundant and diverse biological entities on Earth and exert specific effects on bacterial hosts. The coexistence of phages and bacteria in the intestinal tract is dynamic and interdependent.
Han Shuwen, Ding Kefeng
doaj   +1 more source

Detection of Toxin Production by Bacteroides fragilis: Assay Development and Screening of Extraintestinal Clinical Isolates [PDF]

Clinical Infectious Diseases, 1996
Strains of Bacteroides fragilis that produce an extracellular 20-kD heat-labile toxin have been epidemiologically associated with diarrheal disease. To standardize detection of the B. fragilis toxin (BFT), a detailed description of the methods for identifying BFT production by B. fragilis strains is reported.
L M, Mundy, C L, Sears
openaire   +2 more sources

A review of the role of enterotoxigenic Bacteroides fragilis in the development of colorectal cancer

Basic & Clinical Cancer Research
Enterotoxigenic Bacteroides fragilis (ETBF) plays a significant role in the development and progression of colorectal cancer (CRC) through the production of Bacteroides fragilis toxin (BFT). This toxin activates Wnt, NF-κB, and STAT3 signaling pathways,
Abolfazl Jafari-Sales, Maryam Farahnaki-Sadabadi, Elham Nozohour-Leilabadi, Negin Yagoubi Azar, Maryam Safari, Mehrdad Pashazadeh   +5 more
doaj   +1 more source

Evaluation of enterotoxigenic Bacteroides fragilis correlation with the expression of cellular signaling pathway genes in Iranian patients with colorectal cancer

Infectious Agents and Cancer, 2023
Background Colorectal cancer (CRC) is one of the most common cancers all over the world, and dysbiosis in the gut microbiota may play a role in colorectal carcinogenesis.
Leila Dadgar-Zankbar, Aref Shariati, Narjess Bostanghadiri, Zahra Elahi, Shiva Mirkalantari, Shabnam Razavi, Fatemeh Kamali, Davood Darban-Sarokhalil   +7 more
doaj   +1 more source

Phenotypic and Molecular Characterization of Carbapenem-Heteroresistant Bacteroides fragilis Strains

Antibiotics, 2022
Carbapenem-resistant Bacteroides fragilis strains usually emerge by an insertion sequence (IS) jump into the upstream region of the cfiA carbapenemase gene. However, intermediate or fully resistant cfiA-positive strains also exist. These do not have such
Zain Baaity, Friederike D. von Loewenich, Elisabeth Nagy, László Orosz, Katalin Burián, Ferenc Somogyvári, József Sóki   +6 more
doaj   +1 more source

Gut colonization with an obesity-associated enteropathogenic microbe modulates the premetastatic niches to promote breast cancer lung and liver metastasis

Frontiers in Immunology, 2023
IntroductionObesity, an independent risk factor for breast cancer growth and metastatic progression, is also closely intertwined with gut dysbiosis; and both obese state and dysbiosis promote each other.
Sheetal Parida, Sumit Siddharth, Himavanth R. Gatla, Shaoguang Wu, Guannan Wang, Guannan Wang, Kathleen Gabrielson, Kathleen Gabrielson, Cynthia L. Sears, Cynthia L. Sears, Cynthia L. Sears, Brian H. Ladle, Brian H. Ladle, Dipali Sharma   +13 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source