Results 61 to 70 of about 5,698 (153)

Which bacterial toxins are worthy of validation as markers in colorectal cancer screening? A critical review

Biomedical Papers, 2022
Appropriate screening of early asymptomatic cases can reduce the disease burden and mortality rate of sporadic colorectal cancer (CRC) significantly. Currently, fecal occult blood testing (FOBT) is able to detect up to 80% of ­asymptomatic cases in the ...
Kristyna Mezerova, Vladislav Raclavsky, Lubomir Stary   +2 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Applications of bacteriophages in precision engineering of the human gut microbiome

Engineering Microbiology
As our understanding of the role of the gut microbiome in human diseases deepens, precision engineering of the gut microbiome using bacteriophages has gained significant attention.
Xiaoxian Kuang, Juntao Shen, Linggang Zheng, Yi Duan, Yingfei Ma, Elaine Lai-Han Leung, Lei Dai   +6 more
doaj   +1 more source

Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study

Toxins, 2021
Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is correlated with infections, chronic inflammation, diet, and genetic factors.
Alfonso Piciocchi, Elena Angela Pia Germinario, Koldo Garcia Etxebarria, Silvia Rossi, Lupe Sanchez-Mete, Barbara Porowska, Vittoria Stigliano, Paolo Trentino, Andrea Oddi, Fabio Accarpio, Gian Luca Grazi, Giovanni Bruno, Massimo Bonucci, Massimo Giambenedetti, Patrizia Spigaglia, Fabrizio Barbanti, Slawomir Owczarek, Ida Luzzi, Elisabetta Delibato, Zaira Maroccia, Lorenza Nisticò, Carla Fiorentini, Mauro D’Amato, Roberta De Angelis, Alessia Fabbri   +24 more
doaj   +1 more source

Mechanistic diversity of Bacteroides fragilis toxins and neutralization with single domain antibody

Cell Chemical Biology
Enterotoxigenic Bacteroides fragilis (ETBF) promotes colonic inflammation by secreting metalloenzyme toxins (BFTs). Understanding BFT mechanisms and developing neutralization strategies is critical. Here, we have solved the structures of BFT-1 and BFT-2, revealing that residue 357 in the active site of the catalytic domain explains the diversity of ...
Yucheng Guo, Zhenlin Ouyang, Wenbo He, Qian Qin, Jiaxin Zhang, Ting Yu, Min Jiao, Peter M. Hwang, Fang Zheng, Serge Muyldermans, Yurong Wen   +10 more
openaire   +3 more sources

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Catechins and Their Effect on the Gut Microbiome in Health and Cancer

Phytotherapy Research, EarlyView.
ABSTRACT Catechins are a group of flavonoids found primarily in green tea, fruits, and berries; they play a significant role in the modulation of the gut microbiota, thereby having an impact on gut health and cancer prevention. Owing to their low bioavailability, catechins are transformed by the gut microbiota into various bioactive metabolites such as
Prakash Monika, Bindu Sadanandan, Honnamachanahalli Ramachandraiah Tejashree, Maitreyi Darbha, Kirti Gupta, Srinivas Reneeka   +5 more
wiley   +1 more source

Natural products can be potential inhibitors of metalloproteinase II from Bacteroides fragilis to intervene colorectal cancer

Heliyon
Bacteroides fragilis, a gram negative and obligate anaerobe bacterium, is a member of normal gut microbiota and facilitates many essential roles being performed in human body in normal circumstances specifically in Gastrointestinal or GI tract. Sometimes,
Bushra Arif, Saba Yasir, Muhammad Saeed, M. Qaiser Fatmi   +3 more
doaj   +1 more source

Prevalence and antimicrobial susceptibility of enterotoxigenic extra-intestinal Bacteroides fragilis among 13-year collection of isolates in Kuwait

BMC Microbiology, 2020
Background Some strains of Bacteroides fragilis species are associated with diarrhea as a result of enterotoxin production (bft or fragilysin). Fragilysin is activated by C11 protease (fpn) and together with C10 protease (bfp) play a significant role in ...
Wafaa Jamal, Fatima Bibi Khodakhast, Ameerah AlAzmi, Jόzsef Sόki, Ghayda AlHashem, Vincent O. Rotimi   +5 more
doaj   +1 more source

Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis [PDF]

Infection and Immunity, 1996
Enterotoxigenic Bacteroides fragilis (ETBF) cells produce a 20-kDa heat-labile metalloprotease toxin which is potentially important in the pathogenesis of diarrhea associated with this infection. Previous studies indicate that subconfluent HT29/C1 cells treated with the B.
S S, Koshy, M H, Montrose, C L, Sears
openaire   +2 more sources