Results 21 to 30 of about 5,698 (153)

Experimental study on the effect of bft toxin isolated and purified from clinical isolates of Enterotoxigenic Bacteroides fragilis on the liver, spleen and intestine of mice [PDF]

Basrah Journal of Veterinary Research, 2022
This study includes three parts: isolation of Enterotoxigenic Bacteroid fragilis from 94 stool samples collected from different hospitals in Baghdad city from the beginning of March/2020 to the end of April/2021.
Hussein Khaleefah, Ashwak Jasim
doaj   +1 more source

<i>Bacteroides fragilis</i> toxin in colorectal tumors activates STAT3 and drives microsatellite instability. [PDF]

Ann Med Surg (Lond)
Colorectal cancer (CRC) remains a global malignancy with over 1.9 million new cases annually. Emerging evidence implicates enterotoxigenic Bacteroides fragilis (ETBF) and its toxin (BFT) in activating STAT3 and promoting microsatellite instability (MSI), a novel microbial oncogenic axis.
Mehmood MS, Danaf N.
europepmc   +4 more sources

A Common Pathway for Activation of Host-Targeting and Bacteria-Targeting Toxins in Human Intestinal Bacteria

mBio, 2021
Human gut microbes exhibit a spectrum of cooperative and antagonistic interactions with their host and also with other microbes. The major Bacteroides host-targeting virulence factor, Bacteroides fragilis toxin (BFT), is produced as an inactive protoxin ...
Yiqiao Bao, Andrew A. Verdegaal, Brent W. Anderson, Natasha A. Barry, Jing He, Xiang Gao, Andrew L. Goodman   +6 more
doaj   +1 more source

Cloning and characterization of the Bacteroides fragilis metalloprotease toxin gene [PDF]

Infection and Immunity, 1997
Strains of Bacteroides fragilis that produce a ca. 20-kDa heat-labile protein toxin (termed B. fragilis toxin [BFT]) have been associated with diarrheal disease of animals and humans. BFT alters the morphology of intestinal epithelial cells both in vitro and in vivo and stimulates secretion in ligated intestinal segments of rats, rabbits, and lambs ...
A A, Franco, L M, Mundy, M, Trucksis, S, Wu, J B, Kaper, C L, Sears   +5 more
openaire   +2 more sources

Molecular Modeling and Analysis of Fragilysin, theBacteroides fragilisToxin. [PDF]

Clinical Infectious Diseases, 1997
Bacteroides fragilis is a member of the normal colonic microflora of most mammals and is the anaerobe most commonly isolated from human clinical specimens. It is associated with abscesses, soft-tissue infections, and bacteremias [1]. In the mid 1980s, Myers et al. [la] reported that some strains of B. fragilis produced a toxin that could be detected in
R J, Obiso, D R, Bevan, T D, Wilkins
openaire   +2 more sources

Toxigenic and non-toxigenic patterns I, II and III and biofilm-forming ability in Bacteroides fragilis strains isolated from patients diagnosed with colorectal cancer

Gut Pathogens, 2020
Background Enterotoxigenic Bacteroides fragilis (ETBF) associated with the initiation and progression of colorectal cancer (CRC) has been alarmingly reported all over the world.
Seyedesomaye Jasemi, Mohammad Emaneini, Mohammad Sadegh Fazeli, Zahra Ahmadinejad, Bizhan Nomanpour, Fatemah Sadeghpour Heravi, Leonardo A. Sechi, Mohammad Mehdi Feizabadi   +7 more
doaj   +1 more source

Identification of a Fifth Antibacterial Toxin Produced by a Single Bacteroides fragilis Strain [PDF]

Journal of Bacteriology, 2019
The intestinal microbiota is a diverse microbial ecosystem that provides numerous benefits to humans. The factors that govern its establishment and stability are just beginning to be elucidated. Identification and characterization of antimicrobial toxins produced by its members and their killing range are essential to understanding the ...
Andrew M, Shumaker, Valentina, Laclare McEneany, Michael J, Coyne, Pamela A, Silver, Laurie E, Comstock   +4 more
openaire   +2 more sources

The Bacteroides fragilis toxin fragilysin disrupts the paracellular barrier of epithelial cells [PDF]

Infection and Immunity, 1997
Bacteroides fragilis is a member of the normal colonic microflora of most mammals and is the most commonly isolated anaerobe from human clinical specimens. Some strains produce a toxin (fragilysin, a zinc-metalloproteinase) implicated as a cause of diarrheal disease in farm animals and humans.
R J, Obiso, A O, Azghani, T D, Wilkins
openaire   +2 more sources

Tumorigenic bacteria in colorectal cancer: mechanisms and treatments

Cancer Biology & Medicine, 2022
Colorectal cancer (CRC) is the third most common and the second most fatal cancer. In recent years, more attention has been directed toward the role of gut microbiota in the initiation and development of CRC. Some bacterial species, such as Fusobacterium
Sha Li, Jinyi Liu, Xiangjin Zheng, Liwen Ren, Yihui Yang, Wan Li, Weiqi Fu, Jinhua Wang, Guanhua Du   +8 more
doaj   +1 more source

Enterotoxigenic and nontoxigenic Bacteroides fragilis strains isolated in Brazil

Memorias do Instituto Oswaldo Cruz, 2008
The presence of enterotoxigenic Bacteroides fragilis and nontoxigenic B. fragilis (NTBF) among 109 strains isolated from 1980-2008 in Brazil were investigated by PCR.
Karla R Miranda, Mariana F Dias, Priscilla LS Guimarães, Renata F Boente, Heidi Pauer, Priscila Z Ramos, Laís S Falcão, Eliane de O Ferreira, Ilana T Balassiano, Livia Q Ferreira, Joaquim dos Santos-Filho, Geraldo R de Paula, Eduardo NF Antunes, Katia ES Avelar, Regina MCP Domingues   +14 more
doaj   +1 more source