Activation of Bacteroides fragilis Toxin by a Novel Bacterial Protease Contributes to Anaerobic Sepsis in Mice [PDF]
Nature Medicine, 2016 Bacteroides fragilis is the leading cause of anaerobic bacteremia and sepsis. Enterotoxigenic strains that produce B. fragilis toxin (BFT, fragilysin) contribute to colitis and intestinal malignancy, yet are also isolated in bloodstream infection. It is not known whether these strains harbor unique genetic determinants that confer virulence in extra ...
Sean Crosson +2 more
exaly +5 more sources
The Bacteroides fragilis Toxin Gene Is Prevalent in the Colon Mucosa of Colorectal Cancer Patients. [PDF]
Clinical Infectious Diseases, 2015 Enterotoxigenic Bacteroides fragilis (ETBF) produces the Bacteroides fragilis toxin, which has been associated with acute diarrheal disease, inflammatory bowel disease, and colorectal cancer (CRC). ETBF induces colon carcinogenesis in experimental models.
Drew M Pardoll +2 more
exaly +8 more sources
Bacteroides fragilis Toxin Coordinates a Pro-Carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells [PDF]
Cell Host and Microbe, 2018 Pro-carcinogenic bacteria have the potential to initiate and/or promote colon cancer, in part via immune mechanisms that are incompletely understood. Using ApcMin mice colonized with the human pathobiont enterotoxigenic Bacteroides fragilis (ETBF) as a model of microbe-induced colon tumorigenesis, we show that the Bacteroides fragilis toxin (BFT ...
Drew M Pardoll, Kai Fu, Fengyi Wan
exaly +10 more sources
A Two-Component System Regulates Bacteroides fragilis Toxin to Maintain Intestinal Homeostasis and Prevent Lethal Disease [PDF]
Cell Host and Microbe, 2017 Intestinal microbes are recognized for their role in human disease. Enterotoxigenic Bacteroides fragilis (ETBF) has been implicated in inflammatory bowel disease and colorectal cancer; however, colonization alone is insufficient to cause these illnesses.
Juliane Bubeck Wardenburg +2 more
exaly +5 more sources
In Vitro Evaluation of Propolis Effects on Bacteroides fragilis Toxin-mediated Inflammatory Pathways
Korean Journal of Clinical Laboratory ScienceColorectal cancer (CRC) remains a significant global health concern because of its increasing incidence and mortality rates. Chronic intestinal inflammation is a critical driver in the pathogenesis of CRC, particularly in individuals with inflammatory ...
Soonjae HWANG, Yeram LEE, Ki-Jong RHEE
doaj +2 more sources
Epigenetic Changes Induced by Bacteroides fragilis Toxin. [PDF]
Infect Immun, 2019 Enterotoxigenic Bacteroides fragilis (ETBF) is a Gram-negative, obligate anaerobe member of the gut microbial community in up to 40% of healthy individuals. This bacterium is found more frequently in people with colorectal cancer (CRC) and causes tumor formation in the distal colon of ...
Allen J, Hao S, Sears CL, Timp W.
europepmc +5 more sources
The Mechanism of Bacteroides fragilis Toxin Contributes to Colon Cancer Formation. [PDF]
Malays J Med Sci, 2020 The Bacteroides fragilis (B. fragilis) produce biofilm for colonisation in the intestinal tract can cause a series of inflammatory reactions due to B. fragilis toxin (BFT) which can lead to chronic intestinal inflammation and tissue injury and play a crucial role leading to colorectal cancer (CRC). The enterotoxigenic B.
Cheng WT, Kantilal HK, Davamani F.
europepmc +3 more sources
Glucosylceramide Production Maintains Colon Integrity in Response to Bacteroides fragilis Toxin-Induced Colon Epithelial Cell Signaling. [PDF]
FASEB Journal, 2020 Todd E Fox +2 more
exaly +2 more sources
Bacteroides fragilis toxin promotes gall bladder cancer in mice. [PDF]
Nat MicrobiolChen J +10 more
europepmc +2 more sources
Diversity of the Metalloprotease Toxin Produced by Enterotoxigenic Bacteroides fragilis [PDF]
Infection and Immunity, 2002 ABSTRACT Enterotoxigenic Bacteroides fragilis (ETBF) strains produce a 20-kDa zinc metalloprotease toxin (BFT) associated with diarrheal disease of animals, young children, and adults. BFT stimulates secretion in intestinal loops in vivo and modifies epithelial cell morphology in vitro.
Shaoguang, Wu +4 more
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