Results 31 to 40 of about 32,465 (166)

In Vitro Evaluation of the Therapeutic Potential of Phage VA7 against Enterotoxigenic Bacteroides fragilis Infection

Viruses, 2021
Since the beginning of the 20th century, bacteriophages (phages), i.e., viruses that infect bacteria, have been used as antimicrobial agents for treating various infections. Phage preparations targeting a number of bacterial pathogens are still in use in
Nata Bakuradze, Maya Merabishvili, Khatuna Makalatia, Elene Kakabadze, Nino Grdzelishvili, Jeroen Wagemans, Cedric Lood, Irakli Chachua, Mario Vaneechoutte, Rob Lavigne, Jean-Paul Pirnay, Ivane Abiatari, Nina Chanishvili   +12 more
doaj   +1 more source

The gut microbiota of people with asthma influences lung inflammation in gnotobiotic mice

iScience, 2023
Summary: The gut microbiota in early childhood is linked to asthma risk, but may continue to affect older patients with asthma. Here, we profile the gut microbiota of 38 children (19 asthma, median age 8) and 57 adults (17 asthma, median age 28) by 16S ...
Naomi G. Wilson, Ariel Hernandez-Leyva, Anne L. Rosen, Natalia Jaeger, Ryan T. McDonough, Jesus Santiago-Borges, Michael A. Lint, Thomas R. Rosen, Christopher P. Tomera, Leonard B. Bacharier, S. Joshua Swamidass, Andrew L. Kau   +11 more
doaj   +1 more source

Gut colonization with an obesity-associated enteropathogenic microbe modulates the premetastatic niches to promote breast cancer lung and liver metastasis

Frontiers in Immunology, 2023
IntroductionObesity, an independent risk factor for breast cancer growth and metastatic progression, is also closely intertwined with gut dysbiosis; and both obese state and dysbiosis promote each other.
Sheetal Parida, Sumit Siddharth, Himavanth R. Gatla, Shaoguang Wu, Guannan Wang, Guannan Wang, Kathleen Gabrielson, Kathleen Gabrielson, Cynthia L. Sears, Cynthia L. Sears, Cynthia L. Sears, Brian H. Ladle, Brian H. Ladle, Dipali Sharma   +13 more
doaj   +1 more source

Induction of Persistent Colitis by a Human Commensal, Enterotoxigenic Bacteroides fragilis, in Wild-Type C57BL/6 Mice [PDF]

, 2009
Enterotoxigenic Bacteroides fragilis (ETBF) causes diarrhea and is implicated in inflammatory bowel diseases and colorectal cancer. The only known ETBF virulence factor is the Bacteroides fragilis toxin (BFT), which induces E-cadherin cleavage ...
Rabizadeh, S., Karim, B., Sartor, R. B., Golenbock, D., Sears, C. L., Shin, J., Gan, C. M., Housseau, F., Wu, X., Franco, A. A., Rhee, K.-J., Wu, S., Golub, J. E., Hamad, A. R., Mathews, L. E., Huso, D. L.   +15 more
core   +1 more source

A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer

, 2006
The prevalence of enterotoxigenic Bacteroides fragilis (ETBF) was investigated in stool specimens from 73 patients with colorectal cancer and from 59 control patients. Stool specimens were cultured on Bacteroides Bile Esculin agar and B.
ÜLGER, NURVER, KARAHASAN, AYŞEGÜL, GÜLLÜOĞLU, MAHMUT BAHADIR   +2 more
core   +2 more sources

Promotion of Colitis in B Cell-Deficient C57BL/6 Mice Infected with Enterotoxigenic Bacteroides fragilis

, 2023
Enterotoxigenic Bacteroides fragilis (ETBF) causes colitis and is implicated in inflammatory bowel diseases and colorectal cancer. The ETBF-secreted B. fragilis toxin (BFT) causes cleavage of the adherence junction, the E-cadherin, resulting in the large
Minjeong Jo, Woo-Seung Kim, Da-Hye Kang, Jung-Yoon Yoo, Ju-Eun Hong, Sang-Hyeon Yoo, Chang-Gun Lee, Soonjae Hwang, Ki-Jong Rhee   +8 more
core   +1 more source

Bacteroides fragilis Toxin Induces Intestinal Epithelial Cell Secretion of Interleukin-8 by the E-Cadherin/β-Catenin/NF-κB Dependent Pathway

Biomedicines, 2022
Enterotoxigenic Bacteroides fragilis (ETBF) has emerged as a gut microbiome pathogen that can promote colitis associated cancer in humans. ETBF secretes the metalloprotease, B.
Chang-Gun Lee, Soonjae Hwang, Sun-Yeong Gwon, Chanoh Park, Minjeong Jo, Ju-Eun Hong, Ki-Jong Rhee   +6 more
doaj   +1 more source

Downregulation of the farnesoid X receptor promotes colorectal tumorigenesis by facilitating enterotoxigenic Bacteroides fragilis colonization

Pharmacological Research, 2022
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths in the world. The downregulation of farnesoid X receptor (FXR) is frequently founded in CRC patients.
Suhang Guo, Yi Peng, Yan Lou, Lijuan Cao, Junqing Liu, Nengming Lin, Sheng Cai, Yu Kang, Su Zeng, Lushan Yu   +9 more
doaj   +1 more source

Enterotoxigenic Bacteroides fragilis (ETBF) strains isolated in The Netherlands and Poland are genetically diverse.

Polish journal of microbiology, 2004
Gram-negative anaerobic rods isolated in The Netherlands and Poland from extraintestinal and intestinal sources were identified as Bacteroides fragilis (n = 210) on the basis of Gram staining, growth on selective Bacteroides Bile Esculine medium as black colonies, and biochemical characteristics.
Obuch-Woszczatynski, P, Wintermans, RGF, Belkum, Alex, Endtz, Hubert, Pituch, H, Kreft, DE, Meisel-Mikolajczyk, F, Luczak, M   +7 more
openaire   +3 more sources

The association between fecal enterotoxigenic B. fragilis with colorectal cancer

BMC Cancer, 2019
Background Enterotoxigenic Bacteroides fragilis (ETBF) is an enterotoxin-producing bacterium that possibily has a role in the occurrence and progression of colorectal cancer (CRC) by modulating the mucosal immune response and inducing epithelial cell ...
Fakhri Haghi, Elshan Goli, Bahman Mirzaei, Habib Zeighami   +3 more
doaj   +1 more source