Intratumoral Microbiota in Fueling Cancer and Steering Treatment Response [PDF]
MedComm, Volume 7, Issue 10, October 2026.Emerging research underscores the tumor‐specific colonization of microbiota and the role of intratumoral microbiota in cancer development and treatment resistance across multiple malignancies. Here, we provide a systematic review exploring the latest biotechnological advancements for studying low‐abundance intratumoral microbiota, their origins ...
Minhui Xu +7 more
wiley +2 more sources
Purification and Characterization of His-Tagged Recombinant Bacteroides fragilis Toxin-2 Variants In Vitro and In Vivo [PDF]
ToxinsBacteroides fragilis is a major commensal bacterium of the human colon. However, enterotoxigenic B. fragilis (ETBF) secretes B. fragilis toxin (BFT), a zinc-dependent metalloprotease that cleaves E-cadherin and promotes chronic inflammation and ...
Woo-Seung Kim +4 more
doaj +2 more sources
MicroorganismsEnterotoxigenic Bacteroides fragilis (ETBF) is an intestinal bacterium that secretes the metalloprotease Bacteroides fragilis toxin (BFT), which induces E-cadherin cleavage and interleukin-8 secretion in human intestinal epithelial cell lines.
Woo-Seung Kim +10 more
doaj +2 more sources
The “Direct Structural Disruption” Hypothesis: Bacteroides fragilis Toxin as a Potentiating Cofactor in MASH Pathogenesis [PDF]
ToxinsMetabolic dysfunction-associated steatohepatitis (MASH) is a complex, multifactorial disease heavily influenced by the gut–liver axis. While enterotoxigenic Bacteroides fragilis (ETBF) and its principal virulence factor, B.
Ju-Eun Hong, Soonjae Hwang
doaj +2 more sources
A review of the role of enterotoxigenic Bacteroides fragilis in the development of colorectal cancer
Basic & Clinical Cancer ResearchEnterotoxigenic Bacteroides fragilis (ETBF) plays a significant role in the development and progression of colorectal cancer (CRC) through the production of Bacteroides fragilis toxin (BFT). This toxin activates Wnt, NF-κB, and STAT3 signaling pathways,
Abolfazl Jafari-Sales +5 more
doaj +2 more sources
Gut Pathogens, 2022 Background Colorectal cancer (CRC) is the third most diagnosed cancer and the second most common cause of cancer deaths worldwide. CRC patients present with an increase in pathogens in their gut microbiota, such as polyketide synthase-positive bacteria ...
Manon Oliero +13 more
doaj +2 more sources
The Ambivalent Nature of Bacteroides fragilis and the Interaction with Clostridioides difficile: Benefits and Disadvantages for the Human Host [PDF]
ToxinsBacteroides fragilis is a usually beneficial colonizer of the human gut that can also act as an opportunistic pathogen, causing infection and contributing to the development and progression of important diseases.
Patrizia Spigaglia
doaj +2 more sources
The gut microbiome in colorectal cancer: mechanisms of carcinogenesis and emerging microbiota-targeted therapies [PDF]
Discover OncologyColorectal cancer (CRC) remains a leading cause of cancer-related mortality globally. Beyond established genetic and environmental risk factors, the gut microbiome is now recognized as a pivotal contributor to CRC pathogenesis, progression, and ...
Yue Li +3 more
doaj +2 more sources
Repositioning small molecule drugs as allosteric inhibitors of the BFT‐3 toxin from enterotoxigenic Bacteroides fragilis [PDF]
, 2022 Bacteroides fragilis is an abundant commensal component of the healthy human colon. However, under dysbiotic conditions, enterotoxigenic B. fragilis (ETBF) may arise and elicit diarrhea, anaerobic bacteremia, inflammatory bowel disease, and colorectal ...
Eckhard, Ulrich +19 more
core +1 more source
Gut Pathogens, 2022 Background Enterotoxigenic Bacteroides fragilis (ETBF) has been implicated in colorectal carcinogenesis through the actions of its toxin, B. fragilis toxin (BFT).
Rachel V. Purcell +2 more
doaj +1 more source