Results 81 to 90 of about 963 (132)

Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects

iMeta, Volume 5, Issue 4, August 2026.
Microbiome age (MA) has emerged as an innovative biomarker of biological aging, reflecting host aging trajectories through dynamic alterations in microbial composition, function, and host–microbe interactions across multiple body ecosystems. Diverse computational strategies—including traditional machine learning, deep learning, and multi‐omics ...
Zhexin Ni, Jiaojiao Xie, Zhichun Zhang, Keming Zhang, Jie Ding, Mingyang Chang, Ying Su, Yunan Zhang, Mingfei Yao, Chengyuan Wang, Yan Yan, Wenjie Fang, Hainv Gao, Xuecong Tian, Yangshuo Li, Xinlin Zhu, Wen Zhang, Wanqing Liao, Gaoyuan Xu, Guojing Chen, Xiaoyi Lv, Chaoqin Yu, Weihua Pan, Vadim Molodtsov, Lanjuan Li, Yue Gao, Wei Zhou   +26 more
wiley   +1 more source

Two gut community enterotypes recur in diverse bumblebee species [PDF]

Current Biology, 2015
SummaryPollinating insects are key to the evolutionary and ecological success of flowering plants and enable much of the diversity in the human diet. Gut microbial communities likely impact pollinators in diverse ways, from nutrition to defense against disease [1,2].
Li, Jilian, Powell, J. Elijah, Guo, Jun, Evans, Jay D., Wu, Jie, Williams, Paul, Lin, Qinhui, Moran, Nancy A., Zhang, Zhigang   +8 more
openaire   +2 more sources

Regulation of PD‐1PD‐L1 Immune Checkpoints by Gut Microbiota Metabolites and Their Clinical Translational Research: A Review

Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.
ABSTRACT Background Immune checkpoint inhibitors (ICIs) targeting the PD‐1/PD‐L1 pathway have revolutionized cancer immunotherapy, yet their clinical benefit is constrained by variable response rates and immune‐related adverse events. Aims This review systematically analyzes the molecular mechanisms by which key gut microbiota‐derived metabolites ...
Xuanyou Fang, Shuai Yuan, Weijian Mai
wiley   +1 more source

Machine Learning for TCR Repertoire Epitope Annotation and Pattern Discovery

Immunological Reviews, Volume 340, Issue 1, July 2026.
ABSTRACT T cells are central to adaptive immunity, recognizing antigenic peptides, called epitopes, via the T cell receptor (TCR). The immense diversity and cross‐reactivity of the TCR repertoire makes direct interpretation of antigen specificity from repertoire sequencing challenging.
Romi Vandoren, Vincent Van Deuren, Fabio Affaticati, Sofie Gielis, Kris Laukens, Pieter Meysman   +5 more
wiley   +1 more source

Gut Microbiome–Sleep Crosstalk: Mechanistic Pathways, Dysbiosis Signatures, and Microbiome‐Based Interventions

Brain and Behavior, Volume 16, Issue 6, June 2026.
Gut dysbiosis and sleep disturbances interact bidirectionally through microbial metabolites, immune activation, and neuroendocrine signaling along the gut–brain axis. Microbiome‐based interventions, including probiotics, prebiotics, synbiotics, postbiotics, and fecal microbiota transplantation, may help improve sleep quality and reduce inflammatory ...
Ghaleb Oriquat, Shaker Al‐Hasnaawei, Hayjaa Mohaisen Mousa, Malathi H, Siya Singla, Samir Sahoo, Vimal Arora, Ashish Singh Chauhan, Mehrdad Nourizadeh   +8 more
wiley   +1 more source

Beyond “you are what you eat”: Unlocking gut microbiota‐mediated biotransformation of dietary phytochemicals

iMetaOmics, Volume 3, Issue 2, June 2026.
The “efficacy paradox” of phytochemicals, low bioavailability yet significant health benefits, is associated with gut microbiota, which biotransforms dietary precursors into bioactive metabolites, enabling systemic effects. Thus, health outcomes of diet depend not just on intake “the rainbow”, but on gut microbial metabolism, redefining “you are what ...
Peng Yang, Ren‐You Gan
wiley   +1 more source

Interplay of Diet, Heat Stress, and the Microbiome Shapes Health and Escape Behaviour in Amphibian Larvae

Environmental Microbiology, Volume 28, Issue 6, June 2026.
Diet and temperature jointly shape the gut microbiome and host performance in amphibian larvae. In a multifactorial experiment with Rana temporaria, diet quality, rearing temperature, and heatwave exposure altered microbial communities and predicted metabolic pathways, while host health remained largely stable, suggesting microbiome plasticity and ...
Paula C. Eterovick, Julian Glos, Franziska Burkart, Jörg Overmann, Katharina Ruthsatz   +4 more
wiley   +1 more source

Microbial enterotypes shape the divergence in gut fermentation, host metabolism and growth rate of young goats（Supplementary material）

, 2022
Microbial enterotypes shape the divergence in gut fermentation, host metabolism and growth rate of young goats（Supplementary material）
Guangfu Tang (13946754)
core   +1 more source

A Refined Method for Fecal Microbiota Transplantation Using Nutella

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Fecal microbiota transplantation (FMT) in mice is an evolving research field, often employing oral gavage, which can be stressful and harmful for the animals and time‐consuming for technicians. Voluntary intake methods, such as delivery in Nutella, have successfully been used for drug administration in mice and may likewise be a promising tool
Ida W. Henriksen, Camilla H. F. Hansen, Janne Koch, Dorte B. Sørensen, Dennis S. Nielsen, Christina Bartholdy, Axel K. Hansen   +6 more
wiley   +1 more source

Bacteroides- and Prevotella-enriched gut microbial clusters associate with metabolic risks

Gut Pathogens
The gut microbiome plays a critical role in human health through its influence on numerous physiological functions such as metabolism and immunity, with disruptions in microbial communities increasingly linked to metabolic disorders.
Yi Rou Bah, Kairi Baba, Dayang Nurul Asyiqin Binte Mustafa, Satoshi Watanabe, Aya K. Takeda, Tomoya Yamashita, Kazuyuki Kasahara   +6 more
doaj   +1 more source