Single-cell sequencing reveals cellular heterogeneity and molecular mechanisms in tendon and enthesis injury repair [PDF]
Frontiers in PhysiologyBackgroundTendon and enthesis injuries represent a significant global health challenge, severely impairing patient mobility and self-care abilities while imposing substantial medical burdens.Main BodyPoor clinical outcomes in tendon healing stem from the
Tingming Pan +4 more
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Human spinal enthesis comparative biology of IL-17F and IL-17A reveals greater T-cell IL-17F induction and IL-23 regulation [PDF]
Frontiers in ImmunologyObjectiveAlthough IL-17F is important in psoriasis, the rudimentary biology of IL-17F in the human enthesis remains undefined. We aimed to characterise IL-23-dependent and independent IL-17F production from entheseal innate and adaptive T cells and ...
Nicole McDermott +11 more
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Mesenchymal stem cell activity across a graded scaffold-hydrogel composite biomaterial for tendon-to-bone enthesis repair [PDF]
Bioactive MaterialsThe severity of rotator cuff injury outcomes and a lack of tendon-to-bone enthesis regeneration strategies have inspired advances in biomaterials science to develop methods for interfacial tissue engineering.
Kyle B. Timmer +2 more
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Rotator cuff surgery and semantics: definitions matter [PDF]
Bone & Joint OpenThe imprecise definition of terms used to describe pathological diagnosis in clinical medicine can lead to imprecise treatment concepts and inaccurate recording of outcomes. In this article, we explore the meaning of common terms applied to the pathology
Lars E. Adolfsson +2 more
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Enthesis: not the same in each localisation – a molecular, histological and biomechanical study [PDF]
European Cells & Materials, 2022 The interphase between tendon and bone consists of a highly specialised tissue called enthesis. Typically, the enthesis is described as a succession of four different zones: tendon, non-mineralised fibrocartilage, mineralised fibrocartilage and bone ...
CJ Peniche Silva +7 more
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Radiographic and Histopathologic Evidences of Movement versus Immobilization Effects on Enthesis Formation in Rabbits [PDF]
Iranian Journal of Veterinary Surgery, 2022 Enthesis joins tendon, ligament, or joint capsule to the bone, which are two very different tissues. As a result, it is more prone to stress and increased risk of rupture.
Neda Erfani +3 more
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Making connections: using anatomy to guide tissue engineering approaches at the enthesis [PDF]
European Cells & Materials, 2022 The enthesis demonstrates a distinct highly ordered zonal microanatomy at the osteotendinous/osteoligamentous tissue connection that allows for the smooth transmission of mechanical forces between tissues.
C Loukopoulou, JW Mortimer, JZ Paxton
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Biomarkers for tissue engineering of the tendon-bone interface. [PDF]
PLoS ONE, 2018 The tendon-bone interface (enthesis) is a highly sophisticated biomaterial junction that allows stress transfer between mechanically dissimilar materials.
Lara A Kuntz +6 more
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Advanced strategies for constructing interfacial tissues of bone and tendon/ligament
Journal of Tissue Engineering, 2022 Enthesis, the interfacial tissue between a tendon/ligament and bone, exhibits a complex histological transition from soft to hard tissue, which significantly complicates its repair and regeneration after injury.
Wangwang Luo +11 more
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eLife, 2022 Proper mechanical stimulation can improve rotator cuff enthesis injury repair. However, the underlying mechanism of mechanical stimulation promoting injury repair is still unknown. In this study, we found that Prrx1+ cell was essential for murine rotator
Han Xiao +11 more
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