Bioactive Materials, 2022 Rotator cuff (RC) attaches to humerus across a triphasic yet continuous tissue zones (bone-fibrocartilage-tendon), termed “enthesis”. Regrettably, rapid and functional enthesis regeneration is challenging after RC tear.
Muzhi Li, Hongbin Lu, Lunquan Sun
exaly +3 more sources
3D-printed scaffold-based strategies for enthesis regeneration: a systematic review of the literature [PDF]
Frontiers in Bioengineering and BiotechnologyBackgroundThe enthesis is a specialized transitional tissue that enables load transfer between tendon and bone through a graded tendon–fibrocartilage–bone interface.
Marco Minelli +14 more
doaj +2 more sources
Pathological similarities between degenerative enthesopathy and rheumatic enthesitis: the role of ECM stiffness and Wolff's Law-based mechanical stimulation as a therapeutic strategy [PDF]
Frontiers in Rehabilitation SciencesDegenerative enthesopathy and rheumatic enthesitis have traditionally been regarded as distinct disorders driven by mechanical overload and immune dysregulation, respectively. However, increasing evidence suggests that the mechanobiological links between
Kang Ahn +3 more
doaj +2 more sources
Exercise-primed Trpv4+ progenitors sense mechanical to regulate graded transition in enthesis regeneration [PDF]
Bone & Joint ResearchAims: To identify the molecular mechanisms of mechanotransduction that drive functional regeneration rather than scar formation at the tendon-bone interface, addressing the high clinical failure rates of enthesis injuries.
Shibo Xu +11 more
doaj +2 more sources
Aging Biology of Bone-to-Tendon Healing and the Epigenetic Clock: A Biological-Age Readout of Rotator Cuff Healing Capacity [PDF]
BiomedicinesThe “unexplained failure” of rotator cuff repair is multifactorial, but its structural endpoint is anatomically consistent, i.e., the failure of the tendon-to-bone interface (enthesis) to heal.
Jong Pil Yoon +6 more
doaj +2 more sources
A biodegradable polyurethane adhesive augments tendon–bone interface healing in a rat Achilles repair model [PDF]
Bone & Joint ResearchAims: Surgical repair infrequently restores the native tendon–bone interface (TBI, also referred to as the enthesis), resulting in excessive scar formation, compromised biomechanics, and frequent re-tears.
Vasyl Pastukh +8 more
doaj +2 more sources
Journal of Experimental Orthopaedics, 2016 Background Most ruptures of the native anterior cruciate ligament (ACL) and ACL graft occur at, or near, the femoral enthesis, with the posterolateral fibers of the native ligament being especially vulnerable during pivot landings.
Mélanie L. Beaulieu +2 more
exaly +2 more sources
Visualizing the Achilles Tendon Enthesis: Translational Insights from 7-Tesla MR Microscopy and Histology [PDF]
DiagnosticsBackground/Objectives: The Achilles tendon enthesis (ATE) is a key load-transmitting structure that is frequently affected in musculoskeletal disorders, including insertional tendinopathy, overuse injuries and inflammatory enthesopathies.
Johannes M. Mittendorfer +5 more
doaj +2 more sources
An Anatomical Cadaveric Demonstration of an Ultrasound-Guided Fascial Plane Injection Pathway in the Deep Gluteal Space [PDF]
BioengineeringBackground: Deep gluteal syndrome (DGS) has traditionally been attributed to sciatic nerve entrapment within the deep gluteal space. However, increasing evidence suggests that enthesopathy and soft tissue pathology of the short external rotators may also
Sang-Hyun Kim +8 more
doaj +2 more sources
Enthesis: not the same in each localisation – a molecular, histological and biomechanical study [PDF]
European Cells & Materials, 2022 The interphase between tendon and bone consists of a highly specialised tissue called enthesis. Typically, the enthesis is described as a succession of four different zones: tendon, non-mineralised fibrocartilage, mineralised fibrocartilage and bone ...
CJ Peniche Silva +7 more
doaj +1 more source