Bioactive Materials, 2022 Rotator cuff (RC) attaches to humerus across a triphasic yet continuous tissue zones (bone-fibrocartilage-tendon), termed “enthesis”. Regrettably, rapid and functional enthesis regeneration is challenging after RC tear.
Can Chen, Muzhi Li, Yang Chen
exaly +3 more sources
Single-cell sequencing reveals cellular heterogeneity and molecular mechanisms in tendon and enthesis injury repair [PDF]
Frontiers in PhysiologyBackgroundTendon and enthesis injuries represent a significant global health challenge, severely impairing patient mobility and self-care abilities while imposing substantial medical burdens.Main BodyPoor clinical outcomes in tendon healing stem from the
Tingming Pan +4 more
doaj +2 more sources
Mechanical Strain-Programmed SDC1<sup>+</sup> Sheath Fibroblasts Trigger CXCR4<sup>hi</sup> Neutrophil-Mediated Enthesitis in Ankylosing Spondylitis. [PDF]
Adv Sci (Weinh)In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Lin J +13 more
europepmc +2 more sources
Human spinal enthesis comparative biology of IL-17F and IL-17A reveals greater T-cell IL-17F induction and IL-23 regulation [PDF]
Frontiers in ImmunologyObjectiveAlthough IL-17F is important in psoriasis, the rudimentary biology of IL-17F in the human enthesis remains undefined. We aimed to characterise IL-23-dependent and independent IL-17F production from entheseal innate and adaptive T cells and ...
Nicole McDermott +11 more
doaj +2 more sources
Silk cryogel and electrospun scaffold characterization for bone-tendon interface applications [PDF]
Frontiers in Bioengineering and BiotechnologyIntroductionHard-to-soft tissue interfaces, such as bone-tendon or bone-ligament junctions, remain a challenge to treat. Low healing success rates stem from the complexities at the interface, creating an urgent need for better models to elucidate the ...
Amritha Anup +6 more
doaj +2 more sources
Enthesis: not the same in each localisation – a molecular, histological and biomechanical study [PDF]
European Cells & Materials, 2022 The interphase between tendon and bone consists of a highly specialised tissue called enthesis. Typically, the enthesis is described as a succession of four different zones: tendon, non-mineralised fibrocartilage, mineralised fibrocartilage and bone ...
CJ Peniche Silva +7 more
doaj +1 more source
Radiographic and Histopathologic Evidences of Movement versus Immobilization Effects on Enthesis Formation in Rabbits [PDF]
Iranian Journal of Veterinary Surgery, 2022 Enthesis joins tendon, ligament, or joint capsule to the bone, which are two very different tissues. As a result, it is more prone to stress and increased risk of rupture.
Neda Erfani +3 more
doaj +1 more source
Making connections: using anatomy to guide tissue engineering approaches at the enthesis [PDF]
European Cells & Materials, 2022 The enthesis demonstrates a distinct highly ordered zonal microanatomy at the osteotendinous/osteoligamentous tissue connection that allows for the smooth transmission of mechanical forces between tissues.
C Loukopoulou, JW Mortimer, JZ Paxton
doaj +1 more source
Biomarkers for tissue engineering of the tendon-bone interface. [PDF]
PLoS ONE, 2018 The tendon-bone interface (enthesis) is a highly sophisticated biomaterial junction that allows stress transfer between mechanically dissimilar materials.
Lara A Kuntz +6 more
doaj +1 more source
Advanced strategies for constructing interfacial tissues of bone and tendon/ligament
Journal of Tissue Engineering, 2022 Enthesis, the interfacial tissue between a tendon/ligament and bone, exhibits a complex histological transition from soft to hard tissue, which significantly complicates its repair and regeneration after injury.
Wangwang Luo +11 more
doaj +1 more source