Results 41 to 50 of about 3,707 (163)

The Correlation between the Elastic Modulus of the Achilles Tendon Enthesis and Bone Microstructure in the Calcaneal Crescent

Tomography
Background: The calcaneal enthesis, an osseous footprint where the Achilles tendon seamlessly integrates with the bone, represents a complex interface crucial for effective force transmission.
Kenichiro Doi, Dina Moazamian, Behnam Namiranian, Sheronda Statum, Amir Masoud Afsahi, Takuaki Yamamoto, Karen Y. Cheng, Christine B. Chung, Saeed Jerban   +8 more
doaj   +1 more source

New perspectives in enthesis ultrasound: validation of enthesis fibrocartilage

International Journal of Clinical Rheumatology, 2011
Evaluation of: Aydin SZ, Bas E, Basci O et al.: Validation of ultrasound imaging for Achilles entheseal fibrocartilage in bovines and description of changes in humans with spondyloarthritis. Ann. Rheum. Dis. 69(12), 2165–2168 (2010). Enthesitis, the hallmark of spondyloarthritis is underestimated in clinical practice and improving the knowledge of ...
openaire   +1 more source

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

Advanced Science, EarlyView.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin, Zepeng Su, Yipeng Zeng, Yi Zhou, Chenying Zeng, Weihao Zhang, Qibo Li, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Guan Zheng, Wenhui Yu, Zhongyu Xie   +13 more
wiley   +1 more source

Hedgehog signaling directs cell differentiation and plays a critical role in tendon enthesis healing

npj Regenerative Medicine
A high prevalence of rotator cuff tears presents a major clinical challenge. A better understanding of the molecular mechanisms underlying enthesis development and healing is needed for developing treatments.
Fei Fang, Matthew Casserly, Julia Robbins, Stavros Thomopoulos   +3 more
doaj   +1 more source

Ultrasonographic Evaluation of Entheseal Fibrocartilage in Patients with Psoriatic Arthritis, Athletes and Healthy Controls: A Comparison Study

Diagnostics, 2023
The aims of this study were as follows: (1) To evaluate the entheseal fibrocartilage (EF) during Achilles tendon insertion in patients with Psoriatic Arthritis (PsA) by using power Doppler ultrasound (PDUS), (2) to assess the intra and inter-reader ...
Fabio Massimo Perrotta, Mario Ronga, Silvia Scriffignano, Ennio Lubrano   +3 more
doaj   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Mineral Distributions at the Developing Tendon Enthesis

PLoS ONE, 2012
Tendon attaches to bone across a functionally graded interface, "the enthesis". A gradient of mineral content is believed to play an important role for dissipation of stress concentrations at mature fibrocartilaginous interfaces. Surgical repair of injured tendon to bone often fails, suggesting that the enthesis does not regenerate in a healing setting.
Andrea G Schwartz, Jill D Pasteris, Guy M Genin, Tyrone L Daulton, Stavros Thomopoulos   +4 more
openaire   +4 more sources

Multimaterial Triphasic Scaffold Replicates Enthesis Microenvironment to Modulate Early Cell Responses

Advanced NanoBiomed Research, EarlyView.
A bioinspired triphasic scaffold integrating 3D printed polycaprolactone and electrospun poly(lactic‐co‐glycolic acid) is developed to replicate the organization of the tendon‐to‐bone enthesis. Cyclic mechanical stimulation induces spatially defined cell morphology and lineage‐related gene expression in human mesenchymal stem cells, highlighting the ...
Ginevra Pegollo, Simone Micalizzi, Girish Pattappa, Philipp Stahlhut, Jürgen Groll, Carmelo De Maria, Denitsa Docheva, Giovanni Vozzi   +7 more
wiley   +1 more source

Decoding the mechanical characteristics of the human anterior cruciate ligament entheses through graduated mineralization interfaces

Nature Communications
The anterior cruciate ligament is anchored to the femur and tibia via specialized interfaces known as entheses. These play a critical role in ligament homeostasis and joint stability by transferring forces, varying in magnitude and direction between ...
Jinghua Fang, Xiaozhao Wang, Huinan Lai, Wenyue Li, Xudong Yao, Zongyou Pan, Renwei Mao, Yiyang Yan, Chang Xie, Junxin Lin, Wei Sun, Rui Li, Jiajie Wang, Jiacheng Dai, Kaiwang Xu, Xinning Yu, Tengjing Xu, Wangping Duan, Jin Qian, Hongwei Ouyang, Xuesong Dai   +20 more
doaj   +1 more source

Enthesis regeneration: a role for Gli1+ progenitor cells [PDF]

Development, 2017
The tendon enthesis originates from a specific pool of hedgehog-active Gli1+ progenitor cells that differentiate and produce mineralized fibrocartilage. The current study investigated the regenerative capacity of this cell population by comparing the responses of early postnatal and mature entheses to injury.
Andrea G. Schwartz, Leesa M. Galatz, Stavros Thomopoulos   +2 more
openaire   +2 more sources