Results 71 to 80 of about 63,343 (262)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
A study of the local entropy generation rate in a porous media burner
Archives of Mechanics, 2020 In this paper, the work and performance of the premixed methane-air porous axisymmetrical burner have firstly been simulated numerically using the CFD tools.
I. Mohammadi, J.A. Esfahani, K.C. Kim
doaj +1 more source
Generalized black hole entropy is von Neumann entropy
Physical Review DIt has been argued that, while the individual terms in the generalized entropy, Sgen=A/4GN+Sext, are ill-defined in the semiclassical limit, their sum is well-defined if one takes into account perturbative quantum gravitational effects. The first term diverges as GN→0, and the second diverges due to the infinite entanglement across the horizon which is
Jonah Kudler-Flam +2 more
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Generalized divergences from generalized entropies
Physica A: Statistical Mechanics and its Applications, 2018 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Riveaud, Leonardo +3 more
openaire +4 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A review of entropy generation in microchannels
Advances in Mechanical Engineering, 2015 In this study, a critical review of thermodynamic optimum of microchannels based on entropy generation analysis is presented. Using entropy generation analysis as evaluation parameter of microchannels has been reported by many studies in the literature ...
Mohamed M Awad
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Fluids, 2019 The second law of thermodynamics is indispensable in engineering applications. It allows us to determine if a given process is feasible or not, and if the given process is feasible, how efficient or inefficient is the process.
Rajinder Pal
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Generalized entropy and model uncertainty [PDF]
Journal of Economic Theory, 2019 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +3 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source