Results 81 to 90 of about 341,588 (339)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Entropy Generation Analysis of Laminar Flows of Water-Based Nanofluids in Horizontal Minitubes under Constant Heat Flux Conditions

Entropy, 2018
During the last decade, second law analysis via entropy generation has become important in terms of entropy generation minimization (EGM), thermal engineering system design, irreversibility, and energy saving.
Mehrdad Karimzadehkhouei, Mostafa Shojaeian, Abdolali Khalili Sadaghiani, Kürşat Şendur, M. Pinar Mengüç, Ali Koşar   +5 more
doaj   +1 more source

Entropy Maximization and Instability of Uniformly Magnetized Plasma

, 2012
A regime where a uniformly magnetized plasma could be unstable to a spatial perturbation in the magnetic field is explored. In this regime, a uniformly magnetized state does not maximize the entropy.
Bindoni, Brizard, Chavanis, Fisch, Hameiri, Hinton, Lin, Littlejohn, Morrison, Parker, S. Son, Son, Son, Son, Son, Stix, Sung Joon Moon, Tabak, Tatsuno, Weibel, Wilkie, Yoon   +21 more
core   +1 more source

Generalized $$\alpha $$-observational entropy

Quantum Information Processing
Comment: 13 pages: Accepted for Publication in Quantum Information ...
Sinha, Shivam, Majumdar, Nripendra, Aravinda, S.   +2 more
openaire   +2 more sources

Boltzmann Entropy: Generalization and Applications [PDF]

Journal of Biological Physics, 1997
The object of the paper is to generalize Boltzmann entropy to takeaccount of the subjective nature of a system. The generalized entropyor relative entropy so obtained has been applied to an ecologicalsystem leading to some interesting new results in violation ofexisting physical laws. The entropy was further developed to derive ageneralized macroscopic
C G, Chakrabarti, K, De
openaire   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Two-body recombination in a quantum mechanical lattice gas: Entropy generation and probing of short-range magnetic correlations

, 2010
We study entropy generation in a one-dimensional (1D) model of bosons in an optical lattice experiencing two-particle losses. Such heating is a major impediment to observing exotic low temperature states, and "simulating" condensed matter systems ...
E. Sarajlic, Erich J. Mueller, Stefan K. Baur   +2 more
core   +1 more source

Physical generalizations of the Rényi entropy [PDF]

International Journal of Modern Physics D, 2019
We present a new type of generalization of the Rényi entropy that follows naturally from its representation as a thermodynamic quantity. We apply it to the case of [Formula: see text]-dimensional conformal field theories (CFTs) reduced on a region bounded by a sphere. It is known how to compute their Rényi entropy as an integral of the thermal entropy
openaire   +3 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source