Results 81 to 90 of about 312,386 (294)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Exergy Analysis of a Domestic Refrigerator
Journal of Engineering, 2018 An energy and exergy thermodynamic analysis using EES program was done for a domestic refrigerator working with R-134a using vapor compression refrigeration cycle. The analysis deals with the system component, i.e.
Loauy Abd Al-Azez Mahdi +2 more
doaj +1 more source
Utilizing RNA-Seq Data for Cancer Network Inference
, 2012 An important challenge in cancer systems biology is to uncover the complex network of interactions between genes (tumor suppressor genes and oncogenes) implicated in cancer. Next generation sequencing provides unparalleled ability to probe the expression
Atwal, Gurinder S. +2 more
core +1 more source
A thermodynamically consistent phase-field model for two-phase flows with thermocapillary effects [PDF]
, 2014 In this paper, we develop a phase-field model for binary incompressible (quasi-incompressible) fluid with thermocapillary effects, which allows for the different properties (densities, viscosities and heat conductivities) of each component while ...
Anderson +18 more
core +4 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Entropy generation in a mixed convection Poiseulle flow of molybdenum disulphide Jeffrey nanofluid
Results in Physics, 2018 Entropy analysis in a mixed convection Poiseulle flow of a Molybdenum Disulphide Jeffrey Nanofluid (MDJN) is presented. Mixed convection is caused due to buoyancy force and external pressure gradient.
Aaiza Gul +2 more
doaj +1 more source
Energy analysis of a CHP fuel cell system to meet energy loads of a residential building [PDF]
, 2014 This study deals with the energy analysis of a polymer electrolyte membrane (PEM) fuel cell power system including burner, steam reformer, heat exchanger and water heater.
Ashari, G.R. +3 more
core
Non-equilibrium thermodynamic analysis of double diffusive, nanofluid forced convection in microreactors with radiation effects [PDF]
, 2017 This paper presents a theoretical investigation of the second law performance of double diffusive forced convection in microreactors with the inclusion of nanofluid and radiation effects.
Govone, Lilian +3 more
core +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source