Results 91 to 100 of about 6,410,935 (343)

Inhibition of entry of MERS pseudovirions by lysosomotropic agents or cathepsin inhibitors.

, 2013
(A) Entry into Vero E6 cells of pseudovirions with SARS S protein, uncleaved MERS-CoV S protein or no spike control in the presence of 20mM NH4Cl (bars with rising stripes), 200nM bafilomycin A (bars with horizontal stripes), or medium alone (no ...
Kathryn V. Holmes (214877), Samuel R. Dominguez (221294), Zhaohui Qian (436823)   +2 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion

eLife, 2018
Dengue virus (DV) is a compact, icosahedrally symmetric, enveloped particle, covered by 90 dimers of envelope protein (E), which mediates viral attachment and membrane fusion.
Luke H Chao, Jaebong Jang, Adam Johnson, Anthony Nguyen, Nathanael S Gray, Priscilla L Yang, Stephen C Harrison   +6 more
doaj   +1 more source

Identification of a flavonoid isolated from plum (Prunus domestica) as a potent inhibitor of Hepatitis C virus entry

Scientific Reports, 2017
Hepatitis C virus (HCV) infection is a major cause of chronic liver diseases that often requires liver transplantation. The standard therapies are limited by severe side effects, resistance development, high expense and in a substantial proportion of ...
Mihika Bose, Mohini Kamra, Ranajoy Mullick, S. Bhattacharya, Saumitra Das, A. Karande   +5 more
semanticscholar   +1 more source

Divergent effects of cell environment on HIV entry inhibitor activity

, 2009
OBJECTIVE: Successful HIV vaccine and entry inhibitor development depends on use of assay systems that closely reflect in-vivo activities. Recent reports suggest that the currently most widely used assay format, which relies on the genetically engineered
Rusert, P, Gunthard, H F, Huber, M, Trkola, A, von Wyl, V, Mann, A, Huber M, Trkola A, Mann A, Rusert P, von Wyl V, Gunthard HF   +11 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Screening of Medicinal Herbs Identifies Cimicifuga foetida and Its Bioactive Component Caffeic Acid as SARS-CoV-2 Entry Inhibitors

Viruses
The emergence of SARS-CoV-2 variants highlights the urgent need for novel therapeutic strategies, particularly entry inhibitors that could efficiently prevent viral infection.
Ching-Hsuan Liu, Yu-Ting Kuo, Chien-Ju Lin, Feng-Lin Yen, Shu-Jing Wu, Liang-Tzung Lin   +5 more
doaj   +1 more source

Escape from Human Immunodeficiency Virus Type 1 (HIV-1) Entry Inhibitors

Viruses, 2012
The human immunodeficiency virus (HIV) enters cells through a series of molecular interactions between the HIV envelope protein and cellular receptors, thus providing many opportunities to block infection. Entry inhibitors are currently being used in the
Carol D. Weiss, Christopher J. De Feo
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source