Results 41 to 50 of about 39,645 (195)

The mediating role of neuroimaging-derived biological brain age in the association between risk factors for dementia and cognitive decline in middle-aged and older individuals without cognitive impairment: a cohort study

The Lancet. Healthy Longevity
Summary: Background: Neuroimaging-based brain-age delta has been shown to be a mediator linking cardiovascular risk factors to cognitive function.
Irene Cumplido-Mayoral, MSc, Anna Brugulat-Serrat, PhD, Gonzalo Sánchez-Benavides, PhD, Armand González-Escalante, MSc, Federica Anastasi, PhD, Marta Milà-Alomà, PhD, David López-Martos, MSc, Muge Akinci, MSc, Carles Falcón, PhD, Mahnaz Shekari, MSc, Raffaele Cacciaglia, PhD, Eider M Arenaza-Urquijo, PhD, Carolina Minguillón, PhD, Karine Fauria, PhD, José Luis Molinuevo, MD PhD, Marc Suárez-Calvet, MD PhD, Oriol Grau-Rivera, MD PhD, Verónica Vilaplana, PhD, Juan Domingo Gispert, PhD, R AQUITE AGUILAR, A BETETA GORRITI, A BRUGULAT SERRAT, R E CACCIAGLIA, L CANALS GISPERT, A CAÑAS MARTINEZ, M DEL CAMPO MILAN, C DEULOFEU GOMEZ, R DOMINGUEZ IGLESIAS, M EMILIO, K M E FAURIA, A FERNANDEZ, S D FUENTES JULIAN, P GENIUS SERRA, J D GISPERT LOPEZ, A GONZALEZ ESCALANTE, O GRAU RIVERA, L HERNANDEZ PENAS, G HUESA RODRÍGUEZ, J HUGUET NINOU, L IGLESIAS GAMEZ, I KNEZEVIC, P MARNE ALVAREZ, T MENCHON DIAZ, C MINGUILLON GIL, E PALACIOS, M PASCUAL, W PELKMANS, A POLO BALLESTER, S PRADAS MENDEZ, I A RADOI, B RODRIGUEZ FERNANDEZ, L ROS FREIXEDES, A SALA-VILA, G A SANCHEZ BENAVIDES, M SHEKARI, L SOLSONA HARSTER, A SOTERAS PRAT, L STANKEVICIUTE, M SUAREZ CALVET, M VILANOVA JARAMILLO, N VILOR TEJEDOR   +60 more
doaj   +1 more source

Synergistic Effects of Plasma p‐tau217 and GFAP on Neurodegeneration and Cognitive Decline in Cognitively Unimpaired Individuals [PDF]

Alzheimers Dement
Abstract Background Plasma phosphorylated tau at threonine 217 (p‐tau217) is an accurate biomarker for Alzheimer's pathology. Emerging data suggest that plasma p‐tau217, especially when combined with Glial Fibrillary Acidic Protein (GFAP), predicts cognitive decline up to a decade before clinical onset. However, no studies have quantified its impact on
Cacciaglia R, Escalante A, Ortiz‐Romero P, Grau‐Rivera O, Sánchez‐Benavides G, Day T, Blennow K, Zetterberg H, Molinuevo J, Gispert J, Suárez‐Calvet M, Salvadó G.   +11 more
europepmc   +2 more sources

Associations between remote speech‐based and paper‐and‐pencil cognitive assessments in individuals with Subjective Cognitive Decline [PDF]

Alzheimers Dement
Abstract Background We aimed to provide validation data on Mili‐platform–a remote, automated speech‐based cognitive assessment conducted via telephone–by comparing speech‐derived cognitive scores with standard cognitive paper‐and‐pencil evaluations in a cohort of individuals with Subjective Cognitive Decline (SCD).
Porta‐Mas C, Sánchez‐Benavides G, Mallick E, Tröger J, Linz N, König A, Rădoi A, Rodríguez C, Cañas‐Martínez A, Brugulat‐Serrat A, Canals‐Gispert L, Pérez‐Gutiérrez I, Suárez‐Calvet M, Gispert J, Grau‐Rivera O.   +14 more
europepmc   +2 more sources

Cuidados de nutrición durante el ciclo vital para un envejecimiento saludable [PDF]

, 2016
Durante los últimos 30 años, Chile ha transitado desde la desnutrición infantil alas enfermedades nutricionales por exceso. Actualmente atraviesa un aceleradoproceso de envejecimiento, convirtiéndose en el segundo país más envejecido deAmérica Latina ...
Castillo, Lucía, Pavez, Amaya, Rivera, Carmen, Salvatierra, Vilma   +3 more
core   +1 more source

Envejecimiento saludable y deterioro cognitivo.

Revista de Neuro-Psiquiatría, 2019
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openaire   +4 more sources

Differential contribution of T‐type voltage‐gated calcium channels to vascular reactivity in the aorta and renal artery of healthy rabbits

Experimental Physiology, EarlyView.
Abstract figure T‐type VGCCs contribute to the contraction of the rabbit aorta and modulate both contraction and vasodilation in the rabbit renal artery. α1, alpha 1 adrenergic receptor; ATR, angiotensin II receptor; Ang II, angiotensin II; CaM, calmodulin; Cav3, T‐type voltage‐gated Ca2⁺ channels; cGMP, cyclic guanidine monophosphate; EC, endothelial ...
Andrea Suarez, Sol Guerra‐Ojeda, Manuel Zarzoso, Marta Serna‐García, Jose M. Vila, Eva Serna, Maria D. Mauricio   +6 more
wiley   +1 more source

Level of functional independence and personal and social determinants of healthy aging in Peruvian older adults during COVID-19

MedUNAB
Introduction. The population of older adults reached 900 million in 2010 and is projected to double by 2050. For this reason, it is crucial to understand the factors that affect this population’s autonomy. This study sought to identify individual, social,
Enriquez-Canto, Yordanis, Pizarro-Andrade, Rocío de las Nieves   +1 more
doaj   +1 more source

Detecting early memory changes in preclinical Alzheimer's disease using TabCAT favorites test: Data from the European Prevention of Alzheimer's Disease (EPAD) cohort

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sensitive memory paradigms may allow the detection of subtle memory changes associated with early Alzheimer's pathology in individuals without established clinical symptomatology. METHODS We explored the cross‐sectional association between performance on Tablet‐based Cognitive Assessment Tool (TabCAT) Favorites, a brief ...
Anna Brugulat‐Serrat, Elena Tsoy, Gonzalo Sánchez‐Benavides, Marta Milà‐Alomà, Leslie S. Gaynor, Oriol Grau‐Rivera, Juan Domingo Gispert, Joel H Kramer, Katherine L Possin, for the European Prevention of Alzheimer's Disease (EPAD) Consortium   +9 more
wiley   +1 more source

Relationship between locus coeruleus and slow‐wave sleep in aging and Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep disruption, particularly loss of slow‐wave sleep (SWS), is common in Alzheimer's disease (AD), but its neurobiological underpinnings remain unclear. We investigated whether locus coeruleus (LC) integrity relates to SWS across the AD continuum and whether sex and perivascular spaces (PVSs) modify these associations.
Neus Falgàs, Núria Tort‐Colet, Isabel Martín‐Sobrino, Gerard Mayà, Marta Peña‐González, Salvatore Rudilosso, Carles Gaig, Beatriz Bosch, Aurora Arqueros, Agnès Pérez‐Millan, Adrià Tort‐Merino, Guadalupe Fernández‐Villullas, Gerard Piñol‐Ripoll, Mircea Balasa, Albert Lladó, Manuel Morales Ruiz, Emma Muñoz‐Moreno, Oriol Grau‐Rivera, Alex Iranzo, Lea T. Grinberg, Raquel Sánchez‐Valle   +20 more
wiley   +1 more source

Balneotherapy for the treatment of post-COVID syndrome: a randomized controlled trial

BMC Complementary Medicine and Therapies
Background Post-Acute COVID Syndrome (PACS) is a complex disorder that currently lacks effective evidenced-based therapies to manage it. This randomized controlled trial aims to evaluate the effects of balneotherapy (BT) on PACS symptomatology.
Diana Ovejero, Anna Ribes, Judit Villar-García, Marta Trenchs-Rodriguez, Daniel Lopez, Xavier Nogués, Robert Güerri-Fernandez, Natalia Garcia-Giralt   +7 more
doaj   +1 more source