Results 91 to 100 of about 5,373,729 (260)

Why Environmental Biomarkers Work: Transcriptome-Proteome Correlations and Modeling of Multistressor Experiments in the Marine Bacterium Trichodesmium. [PDF]

J Proteome Res, 2022
Walworth NG, Saito MA, Lee MD, McIlvin MR, Moran DM, Kellogg RM, Fu FX, Hutchins DA, Webb EA.   +8 more
europepmc   +1 more source

Integration of pathologic characteristics, genetic risk and lifestyle exposure for colorectal cancer survival assessment

Nature Communications
The development of an effective survival prediction tool is key for reducing colorectal cancer mortality. Here, we apply a three-stage study to devise a polygenic prognostic score (PPS) for stratifying colorectal cancer overall survival.
Junyi Xin, Dongying Gu, Shuwei Li, Sangni Qian, Yifei Cheng, Wei Shao, Shuai Ben, Silu Chen, Linjun Zhu, Mingjuan Jin, Kun Chen, Zhibin Hu, Zhengdong Zhang, Mulong Du, Hongbing Shen, Meilin Wang   +15 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study

Journal of Translational Medicine
Background Early-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic risk, but the majority of EOPC patients still substantial opportunity to be early-detected thus suffering an unfavorable prognosis.
Yifei Cheng, Lang Wu, Junyi Xin, Shuai Ben, Silu Chen, Huiqin Li, Lingyan Zhao, Meilin Wang, Gong Cheng, Mulong Du   +9 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Effect of genetic and environmental factors on protein biomarkers for common non-communicable disease and use of personally normalized plasma protein profiles (PNPPP)

, 2015
Objective: To study the impact of genetic and lifestyle factors on protein biomarkers and develop personally normalized plasma protein profiles (PNPPP) controlling for non-disease-related variance.Materials and methods: Proximity extension assays were ...
Enroth, Sofia Bosdotter,, Gyllensten, Ulf,, Johansson, Åsa,, Enroth, Stefan,   +3 more
core   +1 more source

Nanoparticles-induced brain injury: prevalence, mechanisms, and implications

Environmental Sciences Europe
Nanotechnology has opened new frontiers in neuroscience and medicine, with nanoparticles (NPs) playing a pivotal role in enhancing drug delivery systems and diagnostic precision.
Khadija Boukholda, Samuel Oluwaseun Olojede, Sabrine Ben Slimen, Eman Elbayoumi, Nada dhaouadi, Alabi Babatunde, Sodiq Kolawole Lawal, Awatef Elwej, Manju P. Maman, Hamadi Fetoui, Kevin Wang, Firas Kobeissy   +11 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Environmental radiation surveillance in Kansas, 1989-1990

, 1990
Prepared by Environmental Radiation and Emergency Preparedness Section, Radiation Control Program, Bureau of Environmental Health ServicesThis publication reports the results of the environmental radiation surveillance programs conducted by the Kansas ...
Kansas Bureau of Environmental Health Services
core   +1 more source