Results 61 to 70 of about 5,880,845 (298)

Deep learning-enhanced geospatial modeling for indoor radon mapping in Jeollabuk-do, South Korea

Geomatics, Natural Hazards & Risk
Radon (Rn-222) is a naturally occurring radioactive gas that poses significant lung cancer risks when accumulated indoors, making accurate predictions of its spatial distribution crucial for public health.
Saro Lee, Liadira Kusuma Widya, Jungsub Lee, Jongchun Lee, Bo Ram Park, Juhee Yoo, Woojin Lee   +6 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Complex noise indicator for noise mapping based on the EU working groups' and Polish results of the annoyance investigations

Archives of Acoustics, 2014
The Noise Directive 2002/49/EU includes obligations for noise mapping for agglomerations above 250 thousand citizens in the first step and later - above 100 thousand people. The noise map of the city consists of, at least, 4 layers of information.
Radosław KUCHARSKI
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

A Nested Ensemble Filtering Approach for Parameter Estimation and Uncertainty Quantification of Traffic Noise Models

Applied Sciences, 2019
In this study, a nested ensemble filtering (NEF) approach is advanced for uncertainty parameter estimation and uncertainty quantification of a traffic noise model.
Kai Huang, Yurui Fan, Liming Dai
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s)

Particle and Fibre Toxicology, 2018
Background Exposure to traffic-derived particulate matter (PM), such as diesel exhaust particles (DEP), is a leading environmental cause of cardiovascular disease (CVD), and may contribute to endothelial dysfunction and development of atherosclerosis. It
Bendik C. Brinchmann, Tonje Skuland, Mia H. Rambøl, Krisztina Szoke, Jan E. Brinchmann, Arno C. Gutleb, Elisa Moschini, Alena Kubátová, Klara Kukowski, Eric Le Ferrec, Dominique Lagadic-Gossmann, Per E. Schwarze, Marit Låg, Magne Refsnes, Johan Øvrevik, Jørn A. Holme   +15 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Preparation of guidance for health risk assessment of environmental noise

, 2010
Evidence has accumulated regarding health effects of environmental noise. The WHO European Centre for Environment and Health, Bonn, has organized several meetings of experts over recent years to examine the current state of knowledge, and to further ...
Brown, AL, Kephalopoulos, S, Kim, R, Schwela, D, Fritschi, L   +4 more
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