Results 61 to 70 of about 502,413 (242)

A higher order PUF complex is central to regulation of C. elegans germline stem cells

Nature Communications
PUF RNA-binding proteins are broadly conserved stem cell regulators. Nematode PUF proteins maintain germline stem cells (GSCs) and, with key partner proteins, repress differentiation mRNAs, including gld-1.
Chen Qiu, Sarah L. Crittenden, Brian H. Carrick, Lucas B. Dillard, Stephany J. Costa Dos Santos, Venkata P. Dandey, Robert C. Dutcher, Elizabeth G. Viverette, Robert N. Wine, Jennifer Woodworth, Zachary T. Campbell, Marvin Wickens, Mario J. Borgnia, Judith Kimble, Traci M. Tanaka Hall   +14 more
doaj   +1 more source

The direct and indirect drivers shaping RNA viral communities in grassland soils

mSystems
Recent studies have revealed diverse RNA viral communities in soils. Yet, how environmental factors influence soil RNA viruses remains largely unknown. Here, we recovered RNA viral communities from bulk metatranscriptomes sequenced from grassland soils ...
Ruonan Wu, Amy E. Zimmerman, Kirsten S. Hofmockel   +2 more
doaj   +1 more source

The Promise of Environmental RNA Research Beyond mRNA

Molecular Ecology
ABSTRACTEnvironmental RNA (eRNA) studies have primarily focused on species detection and community composition through metabarcoding or metatranscriptomics, and on gene expression through messenger RNA (mRNA) abundance analysis. While valuable, this focus overlooks the broader functional roles of other RNA types in cellular metabolism.
Ehsan Pashay Ahi, Tamara Schenekar
openaire   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Environmental RNA as a transformative tool for aquatic ecosystem health assessment: progress and challenges

Ecological Indicators
The assessment of aquatic ecosystem health is undergoing a paradigm shift from traditional physicochemical monitoring to molecular biological monitoring.
Ningxi Zou, Shuhang Wang, Wenhui Qiu, Weijing Kong, Guangwei Wang, Shuping Wang   +5 more
doaj   +1 more source

Linking Environmental DNA and RNA for Improved Detection of the Marine Invasive Fanworm Sabella spallanzanii

Frontiers in Marine Science, 2019
Environmental DNA is increasingly being used in marine invasive species surveillance despite the inability to discriminate between contemporary intracellular (i.e., living) and extracellularly persistent (i.e., legacy) DNA fragments. Environmental RNA is
Ulla von Ammon, Ulla von Ammon, Susanna A. Wood, Olivier Laroche, Olivier Laroche, Anastasija Zaiko, Anastasija Zaiko, Shane D. Lavery, Shane D. Lavery, Graeme J. Inglis, Xavier Pochon, Xavier Pochon   +11 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

miR‐1246 promotes osteosarcoma cell migration via NamiRNA‐enhancer network dependent on Argonaute 2

MedComm
High metastatic propensity of osteosarcoma leads to its therapeutic failure and poor prognosis. Although nuclear activation miRNAs (NamiRNAs) are reported to activate gene transcription via targeting enhancer and further promote tumor metastasis, it ...
Shuai Yang, Qingping Zou, Ying Liang, Dapeng Zhang, Lina Peng, Wei Li, Wenxuan Li, Mengxing Liu, Ying Tong, Lu Chen, Peng Xu, Zhicong Yang, Kaicheng Zhou, Jianru Xiao, Hailin Wang, Wenqiang Yu   +15 more
doaj   +1 more source