Results 91 to 100 of about 2,712,876 (308)

Community engagement and screening of 447 pesticides in the Gellibrand River catchment, Victoria, Australia

Frontiers in Environmental Science
The study presents a comprehensive water quality data collection along the Gellibrand River catchment, over three monitoring campaigns conducted in 2024, to investigate pesticides occurrence. Citizen scientists, guided by the Royal Melbourne Institute of
Caterina Cacciatori, Caterina Cacciatori, Jackie Myers, Giulio Mariani, Bernd Manfred Gawlik, Vincent Pettigrove   +5 more
doaj   +1 more source

Effects of Δtor1 on Yeast Longevity via Chronological Lifespan Assay [PDF]

, 2017
TOR1 is known to extend chronological lifespan in S. cerevisiae. Δtor1 deletion was studied via chronological lifespan assay and environmental oxidative stress test.
Bestwick, Megan, Keyes, Amelia
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Incidence trends of different cancers attributable to smoking and alcohol consumption in Liaoning Province, Northeastern China from 2008 to 2019

BMC Public Health
Objective To analyze the trends in cancer burden attributable to smoking and alcohol consumption in Liaoning Province from 2008 to 2019.  Methods Data on smoking and alcohol consumption were obtained from the Liaoning Provincial Chronic Disease and ...
Li Liu, Qian Ren, Yu Zhang, Ruoyan Yue, Huijuan Mu, Yanxia Li, Huanliang Li, Yuehua Wang, Hongfeng Li, Jingying Li, Chen Li, Wei Sun, Guowei Pan   +12 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Worldwide Research on Plant Defense against Biotic Stresses as Improvement for Sustainable Agriculture [PDF]

, 2018
Agriculture is the basis for food production on a global scale. Sustainable agriculture tries to improve or maintain the quality of food without compromising the environment.
Giménez Caminero, Estela, Manzano Agugliaro, Francisco, Salinas Navarro, María   +2 more
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science
Realgar, an arsenic‐containing traditional Chinese medicine, is commonly used in clinical practice. However, prolonged, excessive, or uncontrolled administration of Chinese patent medicines containing realgar can occasionally induce adverse effects ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
doaj   +1 more source

Environment, epigenetics and neurodegeneration: Focus on nutrition in Alzheimer's disease [PDF]

, 2015
Many different environmental factors (nutrients, pollutants, chemicals, physical activity, lifestyle, physical and mental stress) can modulate epigenetic markers in the developing and adult organism. Epigenetics, in turn, can cause and is associated with
FUSO, ANDREA, LUCARELLI, Marco, NICOLIA, Vincenzina   +2 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source