Results 41 to 50 of about 870,325 (246)

A novel approach for tailoring pesticide screens for monitoring regional aquatic ecosystems

Environmental Advances, 2022
Pesticide monitoring programs are required to understand pesticide contamination in the environment. They can be used to compare existing water quality guidelines and associated their presence with activities related to catchments.
Pulasthi Serasinghe, Hao T.K Nguyen, Thishakya De Silva, Dayanthi Nugegoda, Vincent Pettigrove   +4 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice

BMC Biology
Background Epidemiologic researches show that short sleep duration may affect feeding behaviors resulting in higher energy intake and increased risk of obesity, but the further mechanisms that can interpret the causality remain unclear.
Tingting Du, Shuailing Liu, Honghong Yu, Tian Hu, Lina Huang, Lanyue Gao, Lihong Jia, Jiajin Hu, Yang Yu, Qi Sun   +9 more
doaj   +1 more source

Cardiac autonomic and cortisol stress responses to real operations in surgeons: relationship with individual psychobiological characteristics and experience

BioPsychoSocial Medicine, 2023
Background Surgeons are exposed to high levels of intraoperative stress, which could compromise their psychological well-being in the long term. This study aimed at exploring the effects of real operations on the activity of stress response systems (i.e.,
Luca Carnevali, Elena Bignami, Sara Gambetta, Margherita Barbetti, Matteo Procopio, Antonio Freyrie, Paolo Carbognani, Luca Ampollini, Andrea Sgoifo   +8 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Heart rate variability, daily cortisol indices and their association with psychometric characteristics and gut microbiota composition in an Italian community sample

Scientific Reports
The microbiota–gut–brain axis is a complex communication system that plays a crucial role in influencing various aspects of our physical and mental health.
Sebastiano Ravenda, Leonardo Mancabelli, Sara Gambetta, Margherita Barbetti, Francesca Turroni, Luca Carnevali, Marco Ventura, Andrea Sgoifo   +7 more
doaj   +1 more source

The Mechanism of GABA in Attenuating Neuroinflammation in Alzheimer’s Disease: CP/CEBPα/miR-34a-Mediated Suppression of HDAC2/3 in Astrocytes

Foods
As a widely available dietary supplement, γ-Aminobutyric acid (GABA) exhibits potential for early intervention against Alzheimer’s disease (AD). This study demonstrates that GABA alleviates AD neuroinflammation, and its suppression of astrocytic pro ...
Jingzhu Zhang, Sining Wu, Na Meng, Cui Li, Yue Zhao, Li An   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source