Advanced Science, EarlyView.Lithium‐epigallocatechin gallate nanoparticles (Li‐EGCG NPs) are co‐transplanted with embryonic stem cell‐derived retinal ganglion cells (ESC‐RGCs) to enhance cell survival and therapeutic efficacy in an acute pathological glaucomatous injury model. This synergistic approach protects RGC cells, preserves retinal structure and improves visual function ...
Moxin Chen +14 more
wiley +1 more source
Enzymatic Browning in Artocarpus odoratissimus (Terap) fruits
Advances in Agricultural and Food Research JournalEnzymatic browning, which intensifies in response to tissue stress, remains a major limitation in the food industry as it adversely affects the visual quality and consumer acceptance of products. Artocarpus odoratissimus, a climacteric fruit rich in polyphenols, possesses a shorter shelf-life and is highly perishable, undergoing significant changes in ...
Isniti Richard +3 more
openaire +1 more source
Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis
Advanced Science, EarlyView.DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li +16 more
wiley +1 more source
Chitosan Treatment Promotes Wound Healing of Apple by Eliciting Phenylpropanoid Pathway and Enzymatic Browning of Wounds. [PDF]
Front Microbiol, 2022 Ackah S +6 more
europepmc +1 more source
Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer
Advanced Science, EarlyView.The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang +10 more
wiley +1 more source
Hydrogen Sulfide Inhibits Enzymatic Browning of Fresh-Cut Chinese Water Chestnuts. [PDF]
Front Nutr, 2021 Dou Y +9 more
europepmc +1 more source
cDC1 Subtype‐Specific In Vivo Targeting of Liposomes
Advanced Science, EarlyView.Dendritic cells, particularly the cDC1 subtype, offer a promising target for drug delivery via liposomes due to their pivotal role in immune regulation, allowing for amplified therapeutic responses. Herein, we show an integration of physicochemical characterization and cell experiments to achieve effective in vivo cDC1 targeting through anti‐CLEC9A ...
Maximilian Schaaf +11 more
wiley +1 more source
Control of Enzymatic Browning in Strawberry, Apple, and Pear by Physical Food Preservation Methods: Comparing Ultrasound and High-Pressure Inactivation of Polyphenoloxidase. [PDF]
Foods, 2022 Silva FVM, Sulaiman A.
europepmc +1 more source
Advanced Science, EarlyView.We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin +17 more
wiley +1 more source
Polyphenol oxidase and enzymatic browning in apricot (<i>Prunus armeniaca</i> L.): Effect on phenolic composition and deduction of main substrates. [PDF]
Curr Res Food Sci, 2022 Derardja AE +7 more
europepmc +1 more source