Results 41 to 50 of about 6,346,353 (348)

The protein cost of metabolic fluxes: prediction from enzymatic rate laws and cost minimization

, 2016
Bacterial growth depends crucially on metabolic fluxes, which are limited by the cell's capacity to maintain metabolic enzymes. The necessary enzyme amount per unit flux is a major determinant of metabolic strategies both in evolution and bioengineering.
Bar-Even, Arren, Davidi, Dan, Flamholz, Avi, Liebermeister, Wolfram, Milo, Ron, Noor, Elad   +5 more
core   +3 more sources

Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme [PDF]

, 2010
Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP ...
Andrew C. Hemmert, C. Linn Cadieux, Carol C. Edwards, Douglas M. Cerasoli, Fernando Rodrigues-Lima, John R. Cashman, Jonathan S. Edwards, Lyudmila Tsurkan, Matthew R. Redinbo, Monika Wierdl, Philip M. Potter, Roberto A. Chica, Shane A. Kasten, Stephen L. Mayo, Steven M. Lewis, Tamara C. Otto   +15 more
core   +6 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Laccase production and differential transcription of laccase genes in Cerrena sp. in response to metal ions, aromatic compounds and nutrients

Frontiers in Microbiology, 2016
Laccases can oxidize a wide range of aromatic compounds and are industrially valuable. Laccases often exist in gene families and may differ from each other in expression and function.
Jie eYang, Jie eYang, Guozeng eWang, Guozeng eWang, Tzi Bun eNg, Juan eLin, Juan eLin, Xiuyun eYe, Xiuyun eYe   +8 more
doaj   +1 more source

PCR-RFLP Using BseDI Enzyme for Pork Authentication in Sausage and Nugget Products [PDF]

, 2011
A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using BseDI restriction enzyme had been applied for identifying the presence of pork in processed meat (beef sausage and chicken nugget) including before and after frying ...
Abidin, M. Z. (M), Erwanto, Y. (Y), Rohman, A. (A), Sismindari, S. (Sismindari)   +3 more
core  

The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: interactions at ferrous heme and cysteine thiols [PDF]

, 2009
It has been previously proposed that nitric oxide (NO) is the only biologically relevant nitrogen oxide capable of activating the enzyme soluble guanylate cyclase (sGC). However, recent reports implicate HNO as another possible activator of sGC.
Adrian J. Hobbs, Anderegg, Andrea J. Lee, Bari, Bartberger, Bermejo, Bonner, Brandwein, Burstyn, Craven, Craven, De Witt, DeMaster, Denninger, Derbyshire, DeRubertis, Dierks, Doyle, Drago, Dutton, Dutton, Ellis, Ellis, Farmer, Favaloro, Feelisch, Fukuto, Fukuto, Haddox, Halliwell, Hobbs, Hoshino, Ignarro, Ignarro, Ignarro, Ignarro, Immoos, Irvine, Irvine, Jon M. Fukuto, Judith N. Burstyn, Kamisaki, Katrina M. Miranda, Kim, Lin, Lopez, Maragos, Melisa M. Cherney, Miranda, Miranda, Miranda, Nestor E. Francoleon, Niederhoffer, Paolocci, Paolocci, Patrick J. Farmer, Pervitsky, Pino, Poulos, Rusche, S. Bruce King, Sayed, Scheidt, Schmidt, Serfass, Sha, Shafirovich, Shahidullah, Shen, Smith, Stasch, Stone, Stone, Sulc, Sulc, Thadani, Thomas W. Miller, Turk, Väänänen, Väänänen, Wanstall, Wayland, Wayland, Wolin, Wong, Yonetani   +85 more
core   +2 more sources

Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.

Journal of Immunology, 1972
A sensitive and simple method for the quantitative determination of antibodies is reported. Tubes coated with antigen are incubated with antiserum followed by an enzyme-labeled preparation of anti-immunoglobulin. The enzyme remaining in the tubes after
E. Engvall, P. Perlmann
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Expression and characterization of thermotolerant lipase with broad pH profiles isolated from an Antarctic Pseudomonas sp strain AMS3 [PDF]

PeerJ, 2016
A gene encoding a thermotolerant lipase with broad pH was isolated from an Antarctic Pseudomonas strain AMS3. The recombinant lipase AMS3 was purified by single-step purification using affinity chromatography, yielding a purification fold of ...
Wahhida Latip, Raja Noor Zaliha Raja Abd Rahman, Adam Thean Chor Leow, Fairolniza Mohd Shariff, Mohd Shukuri Mohamad Ali   +4 more
doaj   +2 more sources

The role of the enzyme in the succinate-enzyme-fumarate equilibrium [PDF]

, 1931
The following is an account of an investigation into the role of the enzyme in the succinate-enzyme-fumarate equilibrium. The method consisted in the comparison of the value of the free energy change in this reaction obtained from oxidation-reduction ...
Borsook, Henry, Schott, Hermann F.
core