Enzyme activity below the dynamical transition at 220 K [PDF]
, 1998 Enzyme activity requires the activation of anharmonic motions, such as jumps between potential energy wells. However, in general, the forms and time scales of the functionally important anharmonic dynamics coupled to motion along the reaction coordinate ...
Daniel, Roy M. +5 more
core +3 more sources
Scanning Electron Microscopic Study of the Tongue Papillae Formation
Central Asian Journal of Medical Sciences, 2017 Objectives: To clarify the morphology of the tongue papillae formation and the metabolic characteristics along the papillae distribution in rats. Methods: The experiment was designed as a cross-sectional study and included; a scanning electron and light ...
Shine-Od Dalkhsuren +2 more
doaj +1 more source
Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis. [PDF]
, 2017 Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy.
Castegna, Alessandra +12 more
core +5 more sources
The structural basis of the multi-step allosteric activation of Aurora B kinase
eLife, 2023 Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not ...
Dario Segura-Peña +8 more
doaj +1 more source
Protein dynamics in the reductive activation of a B12-containing enzyme [PDF]
, 2017 B12-dependent proteins are involved in methyl transfer reactions ranging from the biosynthesis of methionine in humans to the formation of acetyl-CoA in anaerobic bacteria.
Goetzl, Sebastian +6 more
core +1 more source
Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation. [PDF]
PLoS ONE, 2012 Cysteine residues in insulin degrading enzyme have been reported as non-critical for its activity. We found that converting the twelve cysteine residues in rat insulin degrading enzyme (IDE) to serines resulted in a cysteine-free form of the enzyme with ...
Eun Suk Song +6 more
doaj +1 more source
Substrate specificity and the effect of calcium on Trypanosomabrucei metacaspase 2 [PDF]
, 2013 Metacaspases are cysteine peptidases found only in yeast, plants and lower eukaryotes, including the protozoa. To investigate the extended substrate specificity and effects of Ca<sup>2+</sup> on the activation of these enzymes, detailed ...
Juliano, L. +7 more
core +1 more source
PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology [PDF]
, 2018 The fibrinolysis proteinase tissue-type plasminogen activator (tPA, also known as PLAT) triggers cell signaling and regulates cell physiology. In PC12 cells, Schwann cells and macrophages, the N-methyl-D-aspartate receptor (NMDA-R) mediates tPA signaling.
Azmoon, Pardis +5 more
core +2 more sources
LPMO as a Key Enzyme in the Sustainable Conversion of Lignocellulosic Biomass [PDF]
Kemija u Industriji, 2023 The importance of the lytic polysaccharide monooxygenase (LPMO) enzyme in the preparation of lignocellulosic raw materials for production in biorefineries has been confirmed in numerous investigations. Therefore, LPMO enzymes were investigated to explore
Tonči Rezić +2 more
doaj +1 more source
The Mg2+ requirements of nonactivated and activated rat liver phosphorylase kinase Inhibition of the activated form by free Mg2+ [PDF]
, 1984 Incubation of rat liver phosphorylase kinase in the presence of MgATP results in a time-dependent increase in activity, i.e., activation. Determination of the magnitude of activation depends, in large part, on the relative concentrations of Mg2+ and ATP ...
Chrisman, Ted D. +2 more
core +1 more source