Activation of oxidoreductases by the formation of enzyme assembly
Scientific Reports, 2023 Biological properties of protein molecules depend on their interaction with other molecules, and enzymes are no exception. Enzyme activities are controlled by their interaction with other molecules in living cells.
Tomoto Ura +6 more
doaj +1 more source
Enzyme activity below the dynamical transition at 220 K [PDF]
, 1998 Enzyme activity requires the activation of anharmonic motions, such as jumps between potential energy wells. However, in general, the forms and time scales of the functionally important anharmonic dynamics coupled to motion along the reaction coordinate ...
Daniel, Roy M. +5 more
core +3 more sources
Scanning Electron Microscopic Study of the Tongue Papillae Formation
Central Asian Journal of Medical Sciences, 2017 Objectives: To clarify the morphology of the tongue papillae formation and the metabolic characteristics along the papillae distribution in rats. Methods: The experiment was designed as a cross-sectional study and included; a scanning electron and light ...
Shine-Od Dalkhsuren +2 more
doaj +1 more source
Master curve of boosted diffusion for ten catalytic enzymes [PDF]
, 2020 Molecular agitation more rapid than thermal Brownian motion is reported for cellular environments, motor proteins, synthetic molecular motors, enzymes, and common chemical reactions, yet that chemical activity couples to molecular motion contrasts with generations of accumulated knowledge about diffusion at equilibrium. To test the limits of this idea,
arxiv +1 more source
Protein dynamics in the reductive activation of a B12-containing enzyme [PDF]
, 2017 B12-dependent proteins are involved in methyl transfer reactions ranging from the biosynthesis of methionine in humans to the formation of acetyl-CoA in anaerobic bacteria.
Bittl, Robert +6 more
core +2 more sources
Information transfer in signaling pathways : a study using coupled simulated and experimental data [PDF]
, 2008 Background: The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown.
Dixon, C. Jane +3 more
core +6 more sources
The structural basis of the multi-step allosteric activation of Aurora B kinase
eLife, 2023 Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not ...
Dario Segura-Peña +8 more
doaj +1 more source
Substrate specificity and the effect of calcium on Trypanosomabrucei metacaspase 2 [PDF]
, 2013 Metacaspases are cysteine peptidases found only in yeast, plants and lower eukaryotes, including the protozoa. To investigate the extended substrate specificity and effects of Ca<sup>2+</sup> on the activation of these enzymes, detailed ...
Juliano, L. +7 more
core +1 more source
Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation. [PDF]
PLoS ONE, 2012 Cysteine residues in insulin degrading enzyme have been reported as non-critical for its activity. We found that converting the twelve cysteine residues in rat insulin degrading enzyme (IDE) to serines resulted in a cysteine-free form of the enzyme with ...
Eun Suk Song +6 more
doaj +1 more source
PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology [PDF]
, 2018 The fibrinolysis proteinase tissue-type plasminogen activator (tPA, also known as PLAT) triggers cell signaling and regulates cell physiology. In PC12 cells, Schwann cells and macrophages, the N-methyl-D-aspartate receptor (NMDA-R) mediates tPA signaling.
Azmoon, Pardis +5 more
core +2 more sources