Results 31 to 40 of about 6,536,634 (394)
mBio, 2019 Carboxyl (C)-terminal processing proteases (CTPs) participate in protective and regulatory proteolysis in bacteria. The PDZ domain is central to the activity of CTPs but plays inherently different regulatory roles.
Chuang-Kai Chueh +5 more
doaj +1 more source
Activation of oxidoreductases by the formation of enzyme assembly
Scientific Reports, 2023 Biological properties of protein molecules depend on their interaction with other molecules, and enzymes are no exception. Enzyme activities are controlled by their interaction with other molecules in living cells.
Tomoto Ura +6 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2021 AMP-activated protein kinase (AMPK) is a key energy sensor regulating the cell metabolism in response to energy supply and demand. The evolutionary adaptation of AMPK to different tissues is accomplished through the expression of distinct isoforms that ...
Elnaz Aledavood +3 more
doaj +1 more source
Information transfer in signaling pathways : a study using coupled simulated and experimental data [PDF]
, 2008 Background: The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown.
Pahle, Jürgen +3 more
core +5 more sources
The structural basis of the multi-step allosteric activation of Aurora B kinase
eLife, 2023 Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not ...
Dario Segura-Peña +8 more
doaj +1 more source
Enzyme localization can drastically affect signal amplification in signal transduction pathways [PDF]
, 2005 Push-pull networks are ubiquitous in signal transduction pathways in both prokaryotic and eukaryotic cells. They allow cells to strongly amplify signals via the mechanism of zero-order ultrasensitivity.
van Albada, Siebe B. +1 more
core +5 more sources
Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation. [PDF]
PLoS ONE, 2012 Cysteine residues in insulin degrading enzyme have been reported as non-critical for its activity. We found that converting the twelve cysteine residues in rat insulin degrading enzyme (IDE) to serines resulted in a cysteine-free form of the enzyme with ...
Eun Suk Song +6 more
doaj +1 more source
Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]
, 2011 Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle +3 more
core +2 more sources
Enzyme-mediated hydrolytic activation of prodrugs
Acta Pharmaceutica Sinica B, 2011 Prodrug design is an important part of drug discovery. Prodrugs can offer many advantages over parent drugs such as increased solubility, enhanced stability, improved bioavailability, reduced side effects, and better selectivity.
Yan-hui Yang +4 more
doaj +1 more source
LPMO as a Key Enzyme in the Sustainable Conversion of Lignocellulosic Biomass [PDF]
Kemija u Industriji, 2023 The importance of the lytic polysaccharide monooxygenase (LPMO) enzyme in the preparation of lignocellulosic raw materials for production in biorefineries has been confirmed in numerous investigations. Therefore, LPMO enzymes were investigated to explore
Tonči Rezić +2 more
doaj +1 more source