Results 101 to 110 of about 1,218,633 (316)

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay [PDF]

, 2018
Ruby Cheung, Gregory W. deHart, Lynne Jesaitis, Stephen J. Zoog, Andrew C. Melton   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Assessing the Feasibility of In Vitro Assays in Combination with Biological Matrices to Screen for Endogenous CYP450 Phenotype Biomarkers Using an Untargeted Metabolomics Approach—A Proof of Concept Study

Metabolites
Background/Objectives: Cytochrome P450 (CYP) enzymes are crucial for drug metabolism, yet inter-individual variability in their activity remains a significant clinical challenge.
Yannick Wartmann, Lana Brockbals, Thomas Kraemer, Andrea E. Steuer   +3 more
doaj   +1 more source

Comparison of C3d immunohistochemical staining to enzyme-linked immunosorbent assay and immunofluorescence for diagnosis of bullous pemphigoid

, 2020
Leo Wang, Ata S. Moshiri, Roberto A. Novoa, Cory L. Simpson, Junko Takeshita, Aimee Payne, Emily Y. Chu   +6 more
openalex   +2 more sources

Enzyme-linked immunosorbent assay for detection of antibodies to murine hepatitis virus [PDF]

, 1979
Robert L. Peters, Michael J. Collins, A J O'Beirne, Pamela A. Howton, S L Hourihan, Schmitt Thomas   +5 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Characterization of α-amylase and antimicrobial activity of Penicillium chrysogenum

Journal of BioScience and Biotechnology
Fungi have been used to produce a number of bioactive compounds that include enzymes and antibacterial agents with unique characteristics in vitro. Penicillium chrysogenum is a mould with great potentials for producing important secondary metabolites ...
Olusegun R. Adeoyo, OlubunmiR. Adewumi
doaj   +1 more source

Comparison of Hemagglutination Inhibition Assay and Enzyme Immunoassay for Determination of Mumps and Rubella Immune Status in Health Care Personnel

, 2013
Shunichi Kumakura, Hiroshi Shibata, Takeshi Isobe, Masahiro Hirose, Miki Ohe, Nobuhiro Nishimura, Keiichi Onoda, Atsushi Nagai, Shuhei Yamaguchi   +8 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Comparison of ortho respiratory syncytial virus enzyme-linked immunosorbent assay and HEp-2 cell culture [PDF]

, 1985
Kenneth Bromberg, Gaylene Tannis, B Daidone, Lorraine Clarke, Marielys Figueroa Sierra   +4 more
openalex   +1 more source