Results 141 to 150 of about 6,124,915 (260)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

GDEE: A Structure-Based Platform for Gene Discovery and Enzyme Engineering. [PDF]

J Chem Inf Model
Souza CS, Correia JPG, Rocha I, Lousa D, Soares CM.   +4 more
europepmc   +1 more source

Designed Local Electric Fields-Promising Tools for Enzyme Engineering. [PDF]

JACS Au, 2023
Siddiqui SA, Stuyver T, Shaik S, Dubey KD.   +3 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

MutexaGPT: an intuition-to-design translator for physics-based enzyme engineering. [PDF]

Nat Comput Sci
Shao Q, Zhong Y, Stull S, Ran X, Ding N, Nehil-Puleo K, Yao R, Xu H, Yang ZJ.   +8 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Engineering MOF-enzyme composites with multi-enzyme loading and recyclability for bioremediation

In this study we focus on the development of advanced MOF-Enzyme composites with the help of pore size engineering and the incorporation of a multi-enzyme system for enhanced biocatalytic performance.
Khalfay, Nida N. A.
core   +1 more source

Rank-guided learning accelerates automated enzyme engineering. [PDF]

Nat Commun
Xu J, Zheng Y, Sundarraj R, Woycechowsky K, Yuchi Z, Yuan Y.   +5 more
europepmc   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Bridging Algorithms and Biocatalysis: Perspectives on AI-Supported Enzyme Engineering. [PDF]

Molecules
Teijeiro-Juiz R, Brück T, Loll B.
europepmc   +1 more source