Results 161 to 170 of about 5,705,534 (301)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Biocatalytic reduction of nitro-sulfonamides: enzyme engineering, process integration, and sustainable pathways to <i>p</i>-aminobenzenesulfonamide. [PDF]

Front Bioeng Biotechnol
Ai R, Muhammad N, Cui Y, Wang L, Wang Y, Weng S, Kakar MU, Khan S, Ahmad S.   +8 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Computationally guided enzyme engineering for regioselective synthesis of fucosylated human milk oligosaccharides. [PDF]

Appl Microbiol Biotechnol
Yang Y, Vega A, Holck J, Planas A, Biarnés X, Zeuner B.   +5 more
europepmc   +1 more source

Machine Learning-Supported Enzyme Engineering toward Improved CO₂-Fixation of Glycolyl-CoA Carboxylase. [PDF]

ACS Synth Biol, 2023
Marchal DG, Schulz L, Schuster I, Ivanovska J, Paczia N, Prinz S, Zarzycki J, Erb TJ.   +7 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Enzyme Microb. Technol.

, 1997
Both the activity and conformational properties of alpha-amylase during the reversed micellar liquid-liquid extraction were investigated by the measurement of enzyme activity and circular dichroism (CD) probe analysis, respectively.
Chen, J. Y., Zhao, N. M., Zhang, X. F., Chang, Q. L.   +3 more
core  

Synzymes: The Future of Modern Enzyme Engineering. [PDF]

Appl Biochem Biotechnol
Palabiyik AA.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Enzyme engineering 8

, 1987
XII+573hlm ...
LASKIN, ALLEN I, WINGARD, DANIEL THOMAS LEMUAEL, ENZYME ENGINEERING 8, MOSBACH, KLAUS   +3 more
core