Results 181 to 190 of about 5,705,534 (301)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Organelle-Targeted Multi-Enzyme Engineering Enables Medium-Chain Fatty Acid Production in <i>Chlamydomonas reinhardtii</i>. [PDF]

J Microbiol Biotechnol
Roh Y, Shin S, Han CH, Eom JI, Park S, Son M, Pan CH, Shin CH, Yamaoka Y.   +8 more
europepmc   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Enzyme Reaction Engineering

CHIMIA, 1993
Christian Wandrey
doaj   +2 more sources

Enzyme Engineering Database (EnzEngDB): a platform for sharing and interpreting sequence-function relationships across protein engineering campaigns. [PDF]

Nucleic Acids Res
Long Y, Abbasinejad F, Li FZ, Reinprecht P, Wittmann B, Kennemur JL, Carder H, Yang J, Lambert T, O'Meara R, Radtke L, Qin Z, Brinkmann-Chen S, Arnold F, Mora A.   +14 more
europepmc   +1 more source

Therapeutic enzyme engineering using a generative neural network. [PDF]

Sci Rep, 2022
Giessel A, Dousis A, Ravichandran K, Smith K, Sur S, McFadyen I, Zheng W, Licht S.   +7 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Expanding the Repertoire of Photoswitchable Unnatural Amino Acids for Enzyme Engineering. [PDF]

Angew Chem Int Ed Engl
Hiefinger C, Marcon M, Pape V, Casadevall G, Lahmy R, Haag C, Nazet J, Bartl M, Bruckmann A, Osuna S, König B, Hupfeld A.   +11 more
europepmc   +1 more source

Enzyme engineering and in vivo testing of a formate reduction pathway. [PDF]

Synth Biol (Oxf), 2021
Wang J, Anderson K, Yang E, He L, Lidstrom ME.   +4 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source