Results 171 to 180 of about 5,705,534 (301)

AI-Driven Enzyme Engineering: Emerging Models and Next-Generation Biotechnological Applications. [PDF]

Molecules
Khan MF, Khan MT.
europepmc   +1 more source

Ultrahigh-Throughput Enzyme Engineering and Discovery in <i>In Vitro</i> Compartments. [PDF]

Chem Rev, 2023
Gantz M, Neun S, Medcalf EJ, van Vliet LD, Hollfelder F.   +4 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Confocal Absorbance-Activated Droplet Sorting (cAADS) for Enzyme Engineering. [PDF]

Adv Sci (Weinh)
Kaba AM, Gounel S, Beneyton T, Buisson L, Baret JC, Mano N.   +5 more
europepmc   +1 more source

Data-driven enzyme engineering to identify function-enhancing enzymes. [PDF]

Protein Eng Des Sel, 2023
Jiang Y, Ran X, Yang ZJ.
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Application of Enzyme Engineering and Synthetic Biology for Modulated Transformation of Fructooligosaccharides (FOSs) to Elucidate the Catalytic Mechanism of Fructofuranosidases. [PDF]

Foods
Chen GL, Chen J, Zhao LZ, Lin B, Zheng FJ, Verma KK, Yang LF.   +6 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Physics-based modeling in the new era of enzyme engineering. [PDF]

Nat Comput Sci
Jurich C, Shao Q, Ran X, Yang ZJ.
europepmc   +1 more source

Nature-inspired Enzyme engineering and sustainable catalysis: biochemical clues from the world of plants and extremophiles. [PDF]

Front Bioeng Biotechnol, 2023
Chatterjee A, Puri S, Sharma PK, Deepa PR, Chowdhury S.   +4 more
europepmc   +1 more source