Results 21 to 30 of about 658,387 (301)
Engineering of GlcNAc-1-phosphotransferase for production of highly phosphorylated lysosomal enzymes for enzyme replacement therapy [PDF]
, 2017 Several lysosomal enzymes currently used for enzyme replacement therapy in patients with lysosomal storage diseases contain very low levels of mannose 6-phosphate, limiting their uptake via mannose 6-phosphate receptors on the surface of the deficient ...
Doray, Balraj +3 more
core +3 more sources
Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors. [PDF]
, 2020 Adenine base editors, which were developed by engineering a transfer RNA adenosine deaminase enzyme (TadA) into a DNA editing enzyme (TadA*), enable precise modification of A:T to Gâ‹®C base pairs. Here, we use molecular dynamics simulations to uncover the
Komor, Alexis C +2 more
core
Evaluation of dissolved organic carbon (DOC) as a measure of cell wall degradation during enzymatic treatment of microalgae [PDF]
, 2016 The feasibility of using Dissolved Organic Carbon (DOC) measurements as a means to assess the efficacy of an enzyme-assisted pretreatment on the recovery of lipids from microalgae was investigated.
Lavecchia, Roberto +2 more
core +1 more source
Frontiers in Microbiology, 2016 Laccases can oxidize a wide range of aromatic compounds and are industrially valuable. Laccases often exist in gene families and may differ from each other in expression and function.
Jie eYang +8 more
doaj +1 more source
Communications Biology, 2021 Wang et al. developed a fluorescence-assisted single-cell methodology (split protease-E. coli ClpXP (SPEC)) to characterise protein-protein interactions for both eukaryotic and prokaryotic species in E. coli cells.
Shengchen Wang +7 more
doaj +1 more source
Analysis of a conserved cellulase transcriptional regulator reveals inducer-independent production of cellulolytic enzymes in Neurospora crassa. [PDF]
, 2013 Cellulose is recalcitrant to deconstruction to glucose for use in fermentation strategies for biofuels and chemicals derived from lignocellulose. In Neurospora crassa, the transcriptional regulator, CLR-2, is required for cellulolytic gene expression and
Coradetti, Samuel +2 more
core +2 more sources
High-efficient production of mushroom polyketide compounds in a platform host Aspergillus oryzae
Microbial Cell Factories, 2023 Background Orsellinic acid (2,4-dihydroxy-6-methylbenzoic acid, OA) and its structural analog o-Orsellinaldehyde, have become widely used intermediates in clinical drugs synthesis.
Haiyan Han +8 more
doaj +1 more source
Marine Drugs, 2021 Penicillium oxalicum k10 isolated from soil revealed the hydrolyzing ability of shrimp chitin and antifungal activity against Sclerotinia sclerotiorum. The k10 chitinase was produced from a powder chitin-containing medium and purified by ammonium sulfate
Xing-Huan Xie +4 more
doaj +1 more source
Enzyme replacement therapies: What is the best option? [PDF]
, 2018 Despite many beneficial outcomes of the conventional enzyme replacement therapy (ERT), several limitations such as the high-cost of the treatment and various inadvertent side effects including the occurrence of an immunological response against the ...
Barar, Jaleh +4 more
core +2 more sources
Research Progress on Fungal Sesterterpenoids Biosynthesis
Journal of Fungi, 2022 Sesterterpenes are 25-carbon terpenoids formed by the cyclization of dimethyl allyl diphosphate (DMAPP) and isopentenyl diphosphate (IPP) as structural units by sesterterpenes synthases.
Ping Zhang +4 more
doaj +1 more source