Results 31 to 40 of about 658,387 (301)

Molecularly Engineered Self-Assembling Membranes for Cell-Mediated Degradation [PDF]

, 2015
The use of peptide engineering to develop self-assembling membranes that are responsive to cellular enzyme activities is reported. The membranes are obtained by combining hyaluronan (HA) and a rationally designed peptide amphiphile (PA) containing a ...
Aimes, Almond, Babel, Banerjee, Banerjee, Behanna, Bott, Burdick, Capito, Caponi, Chau, Chen, Clark, Collier, David-Raoudi, Dehsorkhi, Dicker, Ehrbar, Ferreira, Fonseca, Galler, Galler, Giano, Greenfield, Griffith, Hartgerink, Hinz, Jun, Khelfallah, Khetan, Kim, Kim, Koda, Kähäri, Langer, Langholz, Laurent, Lin, Lutolf, Lutolf, Lutolf, López-De León, Martin-Martin, Mendes, Mendes, Nagase, Nolte, Page-McCaw, Patterson, Schmoekel, Shaw, Solis, Takahashi, Toole, Varani, Vu, Webber, Webber, Werb, Werner, Werner, West, Widgerow, Yang, Zelzer, Zisch   +65 more
core   +1 more source

Directed enzyme evolution: climbing fitness peaks one amino acid at a time [PDF]

, 2009
Directed evolution can generate a remarkable range of new enzyme properties. Alternate substrate specificities and reaction selectivities are readily accessible in enzymes from families that are naturally functionally diverse.
Arnold, Frances H., Tracewell, Cara A.
core   +2 more sources

Engineering the ligninolytic enzyme consortium [PDF]

Trends in Biotechnology, 2015
The ligninolytic enzyme consortium is one of the most-efficient oxidative systems found in nature, playing a pivotal role during wood decay and coal formation. Typically formed by high redox-potential oxidoreductases, this array of enzymes can be used within the emerging lignocellulose biorefineries in processes that range from the production of ...
openaire   +4 more sources

Sesquiterpene synthases from Inonotus obliquus: functional characterization and β-farnesene production

Mycology
The medicinal mushroom Inonotus obliquus is renowned for producing a wide array of pharmacologically active terpenoids, yet the enzymatic basis for this diversity remains partially elusive.
Yingce Duan, Jiaxuan Liu, Zheyong Xue, Pengchao Wang, Jie Zhang, Chengwei Liu   +5 more
doaj   +1 more source

Enzyme Reactor Engineering

CHIMIA, 1975
Design procedures for enzyme reactors do not differ fundamentally from those of conventional catalytic reactors. Initially, the decision must be made whether continuous operation has economic advantages over batchwise processing. Generally, a continuous
Irving J. Dunn
doaj   +1 more source

In Vivo Evolution of Butane Oxidation by Terminal Alkane Hydroxylases AlkB and CYP153A6 [PDF]

, 2009
Enzymes of the AlkB and CYP153 families catalyze the first step in the catabolism of medium-chain-length alkanes, selective oxidation of the alkane to the 1-alkanol, and enable their host organisms to utilize alkanes as carbon sources.
Arnold, Frances H., Chen, Mike M., Koch, Daniel J., van Beilen, Jan B.   +3 more
core   +3 more sources

Chelerythrine-Mediated Growth Inhibition and Resistance Mechanism in Bacillus tropicus

Microorganisms
Chelerythrine (CHE) is a naturally occurring benzophenanthridine alkaloid obtained from plants such as Chelidonium majus L. It has received notable attention in pharmacology and microbial control because of its broad-spectrum activity and marked anti ...
Jueyu Wang, Hongxia Wan, Wenqi Chai, Daizong Cui, Min Zhao   +4 more
doaj   +1 more source

Enhanced lipid extraction from unbroken microalgal cells using enzymes [PDF]

, 2015
The marine microalga Nannochloropsis sp. was chosen as a model organism to investigate the feasibility of using cell wall-degrading enzymes to enhance the recovery of intracellular lipids.
Familiari, Giuseppe, Lavecchia, Roberto, Maffei, Gianluca, Marra, Francesco, Miglietta, Selenia, Petrangeli, Alberto, Valente, Teodoro, Zuorro, Antonio   +7 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source