Results 221 to 230 of about 1,300,330 (300)

Harnessing Methylselenol (CH3SeH): A Highly Effective Platform for Stimuli‐Responsive Delivery With Therapeutic Potential

Advanced Science, EarlyView.
Tools for controlled selenol delivery are crucial for exploring Se‐related biology and medicine, but compound platforms for triggerable release of CH3SeH remain lacking. Herein, we report the first general triggered platform (TD‐MSe) for efficient cyclization release of CH3SeH in live cells.
Wenfang Liang, Liyue Wang, Xuan Wang, Xinran Li, Hao Xing, Lu Sun, Zhen Xi, Long Yi   +7 more
wiley   +1 more source

Preparation and Identification of Antioxidant Peptides in Quinoa. [PDF]

Foods
Zhang Q, Du Q, Li H, Yuan J, Zhao J, Sun F.   +5 more
europepmc   +1 more source

Phosphate‐Engineered DNA Reporters Boost CRISPR‐Cas12a Trans‐Cleavage for Rapid and Sensitive Nucleic Acid Detection

Advanced Science, EarlyView.
We uncover dual CRISPR‐Cas12a trans‐cleavage activities: endonucleolytic cleavage and 3′→5′ exonucleolytic trimming of ssDNA reporters. Mechanism‐guided 3′‐phosphate engineering accelerates substrate cleavage while favoring endonucleolytic processing, enabling Phos‐CRISPR, a rapid (20 min), highly sensitive, and specific platform for nucleic acid ...
Rui Yang, Chong Guo, Minjie Pei, Jiongyu Zhang, Xin Guan, Shuo Zhang, Xingye Liu, Kurt T. Schalper, Lori Avery, Rocco LaSala, David Banach, Changchun Liu   +11 more
wiley   +1 more source

Enhanced Glucose Recovery from Reed Straw (<i>Phragmites australis</i>) via Cascade Microwave-Alkali and Ultrasound-H₂O₂ Pretreatment with Sophorolipid/BSA Supplementation. [PDF]

Polymers (Basel)
Xiong Y, Wang L, Zhou Q, Li F, He F, Liu R, Wang J, Zhan Z, Jia H, Xu C, Cai L.   +10 more
europepmc   +1 more source

Hydrodynamic Selection of Polymorphic Assembly Pathways in Plant Protein Amyloid Fibrils

Advanced Science, EarlyView.
Hydrodynamic conditions are revealed to govern polymorphic assembly of soy protein amyloid fibrils. Distinct flow‐induced drafting, kissing, and docking dynamics direct fibril growth into multiple morphologies, linking fluid mechanics with nanoscale assembly and enabling rational design of functional amyloid materials.
Zejian Xu, Pengfei Yang, Meng Li, Zichen Cao, Tian Lan, Yan Zhang, Weibiao Zhou, Lianzhou Jiang, Xiaonan Sui   +8 more
wiley   +1 more source

Gel Filtration Chromatography-Guided Sequential Hydrolysis of <i>Sthenoteuthis</i><i>oualaniensis</i> Protein: Peptide Distribution and Functional Properties. [PDF]

Foods
Yao Q, Wang H, Yang H, Hong R, Zhong Y, Diao X, Wu W.   +6 more
europepmc   +1 more source

Tip60‐Mediated USP22 Lactylation Drives Glutamine Metabolic Reprogramming via SLC25A5 in TNBC

Advanced Science, EarlyView.
Tip60‐mediated USP22 K134 lactylation, stabilizing SLC25A5 to enhance glutamine metabolism and α‐KG secretion. The secreted α‐KG drives GPR91‐dependent M2 macrophage polarization, promoting triple‐negative breast cancer progression. Targeting this axis synergizes with CB‐839, offering a promising therapeutic strategy for TNBC.
Fang Zhen, Hongyi Wang, Ningzhi Zhang, Le Wang, Huiyuan Tian, Luxi Kang, Zhanpeng Liu, Jing Hu   +7 more
wiley   +1 more source

An Engineered β-Aminopeptidase With Better Product Selectivity for L-Carnosine Production. [PDF]

Chembiochem
Guan BH, Yin WT, Zhao C, Pan J, Xu JH.
europepmc   +1 more source

Phase‐Programmed Microneedles Enable Sequential Hydrogen and Quercetin Release for Scar‐Reduced Regeneration of Burn Wounds

Advanced Science, EarlyView.
A phase‐programmed microneedle patch, comprising a poly (lactic‐co‐glycolic acid) (PLGA) shell and a sulfobutylether‐β‐cyclodextrin (SBECD) core, is designed for sequential hydrogen and quercetin release for scar‐reduced regeneration of burn wounds. ABSTRACT Burn wounds complicated by bacterial infection and fibrotic scarring remain a major clinical ...
Yongnian Zeng, Zhigang Chu, Huiyuan Yang, Wen Zhang, Peng Jiang, Jiapeng Lei, Siyu Zhang, Qiongfang Ruan, Shuhua Liu, Wei Li   +9 more
wiley   +1 more source

Plant Proteins and Bioactive Peptides: Distinguishing Nutritional Quality from Sequence-Dependent Bioactivity. [PDF]

BioTech (Basel)
Sargsyan T, Hakobyan H, Grigoryan H, Stepanyan L, Hovhannisyan A, Saribekyan Z, Tsaturyan A, Hovhannisyan N, Saghyan A, Vicidomini C, Palumbo R, Roviello GN.   +11 more
europepmc   +1 more source