Results 181 to 190 of about 4,886,955 (347)

Inhibition of glutathione peroxidase and the effect on lipid and myoglobin oxidation in beef [PDF]

, 2012
Claeys, Erik, De Smet, Stefaan, Pastsart, Umaporn   +2 more
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Phytochemical analysis and enzyme inhibition of Origanum dictamnus L essential oil through in vitro and in silico methods. [PDF]

Sci Rep
Amato G, De Martino L, Snoussi M, De Feo V, El Hassane A, Noumi E, Caputo L.   +6 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Antidiabetic Potential of Sea Urchin Tripneustes gratilla Nanosuspension Based on In Vitro Enzyme Inhibition, In Vivo Evaluation, and Chemical Profiling Approaches. [PDF]

Curr Issues Mol Biol
Aljohani AKB, Alharbi AS, Alhazmi AB, Hudhayri MN, Almuwallad IB, Alhazmi MA, Almohammadi SM, Alsaleh AI, Aldhafiri A, Eltahir HM, Abouzied MM, Alrbyawi H, Mohamed MS, Abdel-Emam MM, Abdelkarem FM.   +14 more
europepmc   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Targeting Oxalate Production by Combining Enzyme Inhibition and Proteolysis Activation: A Novel Therapeutic Approach for Primary Hyperoxaluria Type 1. [PDF]

J Med Chem
Arias F, Rohilla S, Sixto-López Y, Richard KSE, Das S, Anand SK, Luque-Navarro PM, Bañuelos-Sanchez G, Pacheco-García JL, Gade R, McKinney MP, Kumar D, Maxie J, Corr WR, Pandey N, Kaur H, Ding J, Tan L, Scott E, Nam H, Gottlieb E, Orr AW, Dhanesha N, Yurdagul A, Pey AL, Franco-Montalbán F, Gómez Vidal JA, Rom O, Díaz-Gavilán M.   +28 more
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Phytoconstituents, antioxidant and enzyme inhibition activities of coffee beans through widely targeted metabolomes and <i>in vitro</i> arrays. [PDF]

Food Chem X
Wang Y, Huang Z, He H, Zhou X, Yang D, Shu P, Chen X, Cheng J, Ma Y.   +8 more
europepmc   +1 more source

Inhibition of enzymes by Atebrin [PDF]

Biochimica et Biophysica Acta, 1960
Hemker, H.C., Hülsmann, W.C.
openaire   +2 more sources