Results 191 to 200 of about 4,881,376 (355)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Tannic acid delayed dietary fiber fermentation: dual mechanisms of enzyme inhibition and microbial community dynamics. [PDF]

Front Microbiol
Ren L, Wang H, Luo S, Liu C, Hu X.
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Phytochemical analysis and enzyme inhibition of Origanum dictamnus L essential oil through in vitro and in silico methods. [PDF]

Sci Rep
Amato G, De Martino L, Snoussi M, De Feo V, El Hassane A, Noumi E, Caputo L.   +6 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

An Assessment of Kinase Selectivity, Enzyme Inhibition Kinetics and in Vitro Activity for Several Bruton Tyrosine Kinase (BTK) Inhibitors. [PDF]

ACS Pharmacol Transl Sci
Corrionero A, Zhang X, Alfonso P, Morris PJ, Klumpp-Thomas C, Melani C, McKnight C, Phelan JD, Holland D, Wilson K, Hoyt SB, Roschewski M, Tonge PJ, Wilson W, Ceribelli M, Staudt LM, Thomas CJ.   +16 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Targeting Oxalate Production by Combining Enzyme Inhibition and Proteolysis Activation: A Novel Therapeutic Approach for Primary Hyperoxaluria Type 1. [PDF]

J Med Chem
Arias F, Rohilla S, Sixto-López Y, Richard KSE, Das S, Anand SK, Luque-Navarro PM, Bañuelos-Sanchez G, Pacheco-García JL, Gade R, McKinney MP, Kumar D, Maxie J, Corr WR, Pandey N, Kaur H, Ding J, Tan L, Scott E, Nam H, Gottlieb E, Orr AW, Dhanesha N, Yurdagul A, Pey AL, Franco-Montalbán F, Gómez Vidal JA, Rom O, Díaz-Gavilán M.   +28 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Antidiabetic Potential of Sea Urchin Tripneustes gratilla Nanosuspension Based on In Vitro Enzyme Inhibition, In Vivo Evaluation, and Chemical Profiling Approaches. [PDF]

Curr Issues Mol Biol
Aljohani AKB, Alharbi AS, Alhazmi AB, Hudhayri MN, Almuwallad IB, Alhazmi MA, Almohammadi SM, Alsaleh AI, Aldhafiri A, Eltahir HM, Abouzied MM, Alrbyawi H, Mohamed MS, Abdel-Emam MM, Abdelkarem FM.   +14 more
europepmc   +1 more source