Results 281 to 290 of about 4,886,955 (347)
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Enzyme induction and inhibition
Pharmacology & Therapeutics, 1990The rate and extent of drug metabolism significantly influences drug effect. Enzyme induction by increasing the metabolism of drugs may result in important drug interactions. Other implications of enzyme induction include alterations in the metabolism of endogenous substrates, vitamins and activity of extrahepatic enzyme systems. Similarly a wide range
M, Barry, J, Feely
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Angiotensin converting enzyme inhibition and renin inhibition
Journal of Hypertension, 1989Over a period of several years, methods of measuring circulating angiotensin II have been progressively improved and it has now become possible to measure circulating angiotensin II with a high degree of accuracy. The main ingredients in this new methodology are bonded-phase silica for quantitative angiotensin extraction from biological fluids and ...
J, Nussberger, B, Waeber, H R, Brunner
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ENZYME INHIBITION BY ANTIBODIES
Acta Endocrinologica, 1975ABSTRACT The interest in the inhibition of enzymes by their specific antibodies stems mainly from the fact that these systems can serve as suitable models in the study of neutralization of biologically active molecules in general. The interaction of enzymes with their specific antibodies generally leads to a reduction in their enzymatic ...
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Enzyme inhibition by acetylenic compounds
Biochemical and Biophysical Research Communications, 1970Abstract Soybean lipoxidase and prostaglandin synthetase from sheep seminal vesicles are subject to powerful inhibition by 5,8,11,14-eicosatetraynoic acid, apparently by a slow but irreversible attack on the enzymes. It is postulated that inhibition may result from conversion of the acetylenic compound to a reactive allene by the enzymes studied, as ...
D T, Downing, D G, Ahern, M, Bachta
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Pesticide Detection in Vegetable Crops Using Enzyme Inhibition Methods: a Comprehensive Review
Food Analytical Methods, 2022Heba Bedair +6 more
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Cyclooxygenase enzymes: catalysis and inhibition
Current Opinion in Structural Biology, 2001Scientists working in the field of cyclooxygenase enzymes have witnessed several major advances in the past two years. Crystal structures of fatty acid substrate and prostaglandin product complexes have been elucidated. Elegant site-directed mutagenesis studies have pinpointed the roles of key amino acids within the active site. Together, these results
R G, Kurumbail +2 more
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Angiotensin converting enzyme: Substrate inhibition
Peptides, 1989Phosphate, borate, and Tris inhibit angiotensin converting enzyme (ACE), but HEPES buffer is inert. Measurements of substrate inhibition were made in HEPES buffer at pH 7.0 and 25 degrees C and 37 degrees C. Substrate inhibition was marked and goes to completion.
J R, Schullek, I B, Wilson
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Chemical Aspects of Enzyme Inhibition
Science, 1957The use of chemical reagents as enzyme inhibitors has yielded information concerning the mechanism of inhibition and the role in catalysis played by active groups on the protein apoenzyme, the coenzyme, or the metal component. Inhibition analysis has also furnished valuable clues concerning the architecture, chemical properties, and ...
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