Results 91 to 100 of about 1,224,230 (307)

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

Periplasmic binding proteins Bug69 and Bug27 from Bordetella pertussis are in vitro high‐affinity quinolinate binders with a potential role in NAD biosynthesis

FEBS Open Bio
Bordetella's genome contains a large family of periplasmic binding proteins (PBPs) known as Bugs, whose functions are mainly unassigned. Two members, Bug27 and Bug69, have previously been considered potential candidates for the uptake of small pyridine ...
Leonardo Sorci, Gabriele Minazzato, Adolfo Amici, Francesca Mazzola, Nadia Raffaelli   +4 more
doaj   +1 more source

Computer-aided characteristics of proteins as potential precursors of bioactive peptides

Polimery, 2003
Proteins, apart from their basic functions, may play the role of precursors of the peptides that regulate the body functions and/or show anti­hypertensive, antithrombotic, antiamnestic, immunomodulating and other activities. Computer analysis of 109
Jerzy Dziuba
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Shaping immune landscape of colorectal cancer by cholesterol metabolites

EMBO Molecular Medicine
Cancer immunotherapies have achieved unprecedented success in clinic, but they remain largely ineffective in some major types of cancer, such as colorectal cancer with microsatellite stability (MSS CRC).
Yibing Bai, Tongzhou Li, Qinshu Wang, Weiqiang You, Haochen Yang, Xintian Xu, Ziyi Li, Yu Zhang, Chengsong Yan, Lei Yang, Jiaqian Qiu, Yuanhua Liu, Shiyang Chen, Dongfang Wang, Binlu Huang, Kexin Liu, Bao- Liang Song, Zhuozhong Wang, Kang Li, Xin Liu, Guangchuan Wang, Weiwei Yang, Jianfeng Chen, Pei Hao, Zemin Zhang, Zhigang Wang, Zheng-Jiang Zhu, Chenqi Xu   +27 more
doaj   +1 more source

Cap-independent translation of RNAs: structure and function of the internal ribosomal entry site

, 1990
3
Christopher U. T. Hellen, Gary W. Witherell, Tatyana Pestova, Sung K. Jang, Eckard Wimmer   +4 more
core  

Decoupling enzyme catalysis from thermal denaturation [PDF]

, 2010
The equilibrium model (EM) (Daniel et al., 2001) postulates two forms of a folded enzyme, one catalytically active (Eact) and the other inactive (Einact), which interconvert via a fast thermal equilibrium (Keq) (Figure A). This model for enzyme catalysis
Easter, Ashley Davys
core  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Thioesterases in fruit and the generation of high impact aroma chemicals [PDF]

, 2008
Volatile organosulphur compounds (VOSCs) are key ingredients in the aroma of tropical fruit where they are active as both free thiols and the respective thioesters.
Tapp, Edward
core  

Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]

, 2008
Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Sanschagrin, François, Tom Clarke, Catherine Paradis-Bleau, Blewett, Ann, Roger C Levesque, Clark, Tom, Paradis-Bleau , Catherine, Ann Blewett, Adrian Lloyd, Levesque, Roger C., Lloyd, Adrian, François Sanschagrin, Timothy DH Bugg, Bugg, Tim   +13 more
core   +1 more source