Results 71 to 80 of about 1,224,230 (307)

Enzyme activity and flexibility at very low hydration [PDF]

, 2005
Recent measurements have demonstrated enzyme activity at hydrations as low as 3%. This raises the question of whether hydration-induced enzyme flexibility is important for activity. Here, to address this, picosecond dynamic neutron scattering experiments
Kurkal, V., Kurkal, Vandana, Smith, Jeremy C., Tehei, M., Finney, John L., Dunn, Rachel V., Tehei, Moeava, Dunn, R.V., Daniel, R.M., Daniel, Roy M.   +9 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Dual-Enzyme-Catalyzed Synthesis of Enantiocomplementary Polyesters

, 2019
Herein, a series of enantiocomplementary polyesters with either (S)- or (R)-configurations were successfully prepared by applying a dual-enzyme biocatalytic system.
Xianfu Lin, Weihua Xu (56657), Qi Wu (263110), Jian Xu, Qi Wu, Jian Xu (31545), Yu Zhang (12946), Yujing Hu (4097848), Weihua Xu, Xianfu Lin (1443307), Yu Zhang, Yujing Hu   +11 more
core   +1 more source

From sequence to enzyme mechanism using multi-label machine learning [PDF]

, 2014
Background: In this work we predict enzyme function at the level of chemical mechanism, providing a finer granularity of annotation than traditional Enzyme Commission (EC) classes.
De Ferrari, Luna; id_orcid, De Ferrari, L., John BO Mitchell, Luna De Ferrari, Mitchell, J.B O., Mitchell, John B O   +5 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Isolation and Characterization of Sepiapterin Reductase from Drosophila melanogaster

Pteridines, 1993
Sepiapterin reductase, an enzyme that catalyses the synthesis of tetrahydrobiopterin (BH4). was partially purified from Drosophila melanogaster using ammonium sulfate fractionation. Affi-gel blue chromatography and hydroxyapatite chromatography.
Yoon K.H., Cha K.W., Park S.I., Yim J.J.
doaj   +1 more source

The molecular basis of the effect of temperature on enzyme activity [PDF]

, 2010
Experimental data show that the effect of temperature on enzymes cannot be adequately explained in terms of a two-state model based on increases in activity and denaturation.
Oudshoorn, Matthew Leslie, Kelly, S.M., Price, N.C., Weinberg, C.S., Monk, C.R., Oudshoorn, M.L., Monk, Colin R., Danson, Michael J., Price, Nicholas C., Danson, M.J., Lee, Charles Kai-Wu, Peterson, Michelle E., Lee, C.K., Peterson, M.E., Weinberg, Cristina S., Daniel, R.M., Daniel, Roy M., Kelly, Sharon M.   +17 more
core   +1 more source

Enzyme-substrate interaction modeling strategies.

, 2022
(A) Current machine learning-directed evolution strategies, which involve design-build-test-model-learn cycles measuring protein variant activity on a single substrate of interest.
Samuel Goldman (1699888), Connor W. Coley (1496653), Ria Das (12072859), Kevin K. Yang (4528963)   +3 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source