Results 51 to 60 of about 1,224,230 (307)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Multiple Mechanisms for the Action of Chymase Inhibitors

Journal of Pharmacological Sciences, 2012
Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various genes, such as transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 ...
Shinji Takai, Denan Jin, Mizuo Miyazaki
doaj   +1 more source

Dimerization of β-Site β-Amyloid Precursor Protein-cleaving Enzyme [PDF]

Journal of Biological Chemistry, 2004
Cleavage of the beta-amyloid precursor protein (APP) by the aspartyl protease beta-site APP-cleaving enzyme (BACE) is the first step in the generation of the amyloid beta-peptide, which is deposited in the brain of Alzheimer's disease patients.
Gil G, Westmeyer, Michael, Willem, Stefan F, Lichtenthaler, Glenn, Lurman, Gerd, Multhaup, Irmgard, Assfalg-Machleidt, Karina, Reiss, Paul, Saftig, Christian, Haass   +8 more
openaire   +2 more sources

Enzyme-Instructed Assembly and Disassembly Processes for Targeting Downregulation in Cancer Cells

, 2018
Cancer cells differ from normal cells in both gain of functions (i.e., upregulation) and loss of functions (i.e., downregulation). While it is common to suppress gain of function for chemotherapy, it remains challenging to target downregulation in cancer
Zhaoqianqi Feng (2991264), Huaimin Wang (629719), Jie Li (15030), Rong Zhou (138287), Bing Xu (69508)   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1[S]

Journal of Lipid Research, 2014
Cytochrome P450 (P450 or CYP) 46A1 is expressed in brain and has been characterized by its ability to oxidize cholesterol to 24S-hydroxycholesterol. In addition, the same enzyme is known to further oxidize 24S-hydroxycholesterol to the 24,25- and 24,27 ...
Sandeep Goyal, Yi Xiao, Ned A. Porter, Libin Xu, F. Peter Guengerich   +4 more
doaj   +1 more source

Metabolic Engineering of Nicotiana benthamiana to Produce Cannabinoid Precursors and Their Analogues

Metabolites, 2022
In recent years, the perspective towards the use of cannabis has slowly shifted from being an illicit drug to a medicinal plant. The pathway and enzymes involved in the production of cannabinoids are known; however, studies evaluating the production of ...
Vaishnavi Amarr Reddy, Sing Hui Leong, In-Cheol Jang, Sarojam Rajani   +3 more
doaj   +1 more source

Enzyme-enzyme co-abundance analysis.

, 2017
(a) Enzyme-enzyme co-abundance network. Nodes and edges indicate enzymes and their correlations. Positive (r > 0.6) and negative (r < -0.6) correlations were indicated as red and blue, respectively.
Atsumi Tomita (3797761), Shunsuke Nishino (2554585), Hiroshi Shimizu (76745), Fumio Matsuda (230101), Syohei Kinoshita (3797758)   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source