Results 251 to 260 of about 2,250,147 (369)

Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition

Advanced Science, EarlyView.
A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li, Fang Ye, Yucheng Zheng, Jie Wang, Haoran Peng, Lili Zhu, Lili Chen, Tao Yu, Huan Ge, Jiaqi He, Binghao Zhang, Jiayun Wu, Zhiyi Zhang, Liangliang Jiang, Geng Chen, Ping Zhao, Ke Lan, Zhenjiang Zhao, Xuhong Qian, Ke Xu, Yang Du, Honglin Li   +21 more
wiley   +1 more source

Recent Progress in Enzyme Immobilization to Metal-Organic Frameworks to Enhance the CO₂ Conversion Efficiency. [PDF]

Molecules
Cao Y, Yang P, Zhao R, Wang F.
europepmc   +1 more source

Microneedle Patch for In Situ Neutrophil Monitoring

Advanced Science, EarlyView.
An in situ chromogenic microneedle patch that achieves daily blood neutrophil monitoring without vascular invasion or laboratory apparatus is developed. The detection ability is well demonstrated in a chemotherapy‐induced neutropenic rat model and can be read out using a mobile phone application.
Ziyi Lu, Ruisi Cai, Tianao Xie, Sheng Zhao, Sarun Juengpanich, Win Topatana, Shijie Li, Jiasheng Cao, Jiahao Hu, Tianen Chen, Jiachen Chen, Jicheng Yu, Tao Sheng, Wentao Zhang, Hao Wang, Jiahuan You, Yukai Shan, Yuchao Sun, Ruijing Shen, Zhengjie Zhao, Kangfan Ji, Ziqi Gao, Xinmin Yu, Xiujun Cai, Zhen Gu, Yuqi Zhang, Mingyu Chen   +26 more
wiley   +1 more source

Recent Advances in Enzymatic Biofuel Cells to Power Up Wearable and Implantable Biosensors. [PDF]

Biosensors (Basel)
Fredj Z, Rong G, Sawan M.
europepmc   +1 more source

Design, Synthesis, and Application of Immobilized Enzymes on Artificial Porous Materials

Advanced Science, EarlyView.
This review comprehensively summarizes the advances in research for immobilized enzymes on artificial porous materials. It highlights the advantages of bottom‐up strategy, post‐synthesis modification and composite method of metal‐organic frameworks (MOFs), covalent organic frameworks (COFs) and hydrogen‐bonded organic frameworks (HOFs) and emphasizes ...
Lu Ran, Yuan Lu, Li Chen, Mengru He, Zhangshuang Deng   +4 more
wiley   +1 more source

Self-sufficient biocatalytic cascade for the continuous synthesis of danshensu in flow. [PDF]

Appl Microbiol Biotechnol
Marchini V, Paradisi F.
europepmc   +1 more source

Prussian‐Blue Catalysis and NFC Synergy: a Battery‐Free Laser‐Induced Graphene‐Based Platform for Urine Glucose Monitoring at Point‐of‐Care

Advanced Science, EarlyView.
In this study, Merkoçi and his research group present a polymer‐based synthesis to enhance the stability of Prussian blue (PB) nanoparticles. The resulting PB‐infused catalytic hetero‐interface architecture (PB‐CHIA) achieves complete two‐dimensional (2D) and three‐dimensional (3D) substrate coverage (glassy carbon and laser‐induced graphene electrodes)
Sinan Uzunçar, Gabriel Maroli, Massimo Urban, Arben Merkoçi   +3 more
wiley   +1 more source

AFM for Studying the Functional Activity of Enzymes. [PDF]

Biomolecules
Ivanova IA, Valueva AA, Ershova MO, Pleshakova TO.   +3 more
europepmc   +1 more source

Pushing the Frontiers: Artificial Intelligence (AI)‐Guided Programmable Concepts in Binary Self‐Assembly of Colloidal Nanoparticles

Advanced Science, EarlyView.
Colloidal nanoparticles self‐assembly advances towards intelligent, customized assembly through precise control of binary co‐assemblies. This review explores the evolution from monolithic to binary assemblies, highlighting how the AI‐guided programmable assembly approach has the potential to shift from passive assembly to active intelligent design.
Cancan Li, Lindong Ma, Zhenjie Xue, Xiao Li, Shan Zhu, Tie Wang   +5 more
wiley   +1 more source

An Innovative Enzymatic Surface Plasmon Resonance-Based Biosensor Designed for Precise Detection of Glycine Amino Acid. [PDF]

Biosensors (Basel)
Quintanilla-Villanueva GE, Rodríguez-Quiroz O, Sánchez-Álvarez A, Rodríguez-Delgado JM, Villarreal-Chiu JF, Luna-Moreno D, Rodríguez-Delgado MM.   +6 more
europepmc   +1 more source