Results 101 to 110 of about 3,038,812 (378)

In Vivo Evolution of Butane Oxidation by Terminal Alkane Hydroxylases AlkB and CYP153A6 [PDF]

, 2009
Enzymes of the AlkB and CYP153 families catalyze the first step in the catabolism of medium-chain-length alkanes, selective oxidation of the alkane to the 1-alkanol, and enable their host organisms to utilize alkanes as carbon sources.
Arnold, Frances H., Chen, Mike M., Koch, Daniel J., van Beilen, Jan B.   +3 more
core   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Effective inter-symbol interference mitigation with a limited amount of enzymes in molecular communications [PDF]

arXiv, 2016
In molecular communication via diffusion (MCvD), the inter-symbol interference (ISI) is a well known severe problem that deteriorates both data rates and link reliability. ISI mainly occurs due to the slow and highly random propagation of the messenger molecules, which causes the emitted molecules from the previous symbols to interfere with molecules ...
arxiv  

The nitric oxide response in plant-associated endosymbiotic bacteria [PDF]

, 2011
Nitric oxide (NO) is a gaseous signalling molecule which becomes very toxic due to its ability to react with multiple cellular targets in biological systems. Bacterial cells protect against NO through the expression of enzymes that detoxify this molecule
Andrew J. Gates, Baudouin, Bedmar, Besson-Bard, Bobik, Bueno, Bueno, Cristina Sánchez, Cruz-Ramos, Cueto, David J. Richardson, de Bruijn, del Giudice, Delgado, Elvers, Eulogio J. Bedmar, Frey, Gardner, Gardner, Gilles-Gonzalez, Girard, González, Gómez-Hernández, Hauser, Horchani, Hughes, Juan J. Cabrera, Justino, Kaneko, María J. Delgado, Meakin, Meakin, Meilhoc, Meilhoc, Mesa, Mesa, Mesa, Mills, Moreau, Oldroyd, Pessi, Pii, Pittman, Poole, Pullan, Shimoda, Socorro Mesa, Spiro, Spiro, Sánchez, Sánchez, Sánchez, Tominaga, Torres, Tucker, Tucker, Tucker, van Wonderen   +57 more
core   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Structures, Functions, and Mechanisms of Filament Forming Enzymes: A Renaissance of Enzyme Filamentation [PDF]

arXiv, 2019
Filament formation by non-cytoskeletal enzymes has been known for decades, yet only relatively recently has its wide-spread role in enzyme regulation and biology come to be appreciated. This comprehensive review summarizes what is known for each enzyme confirmed to form filamentous structures in vitro, and for the many that are known only to form large
arxiv  

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Synthesis of α,β-unsaturated esters via a chemo-enzymatic chain elongation approach by combining carboxylic acid reduction and Wittig reaction

Beilstein Journal of Organic Chemistry, 2015
α,β-Unsaturated esters are versatile building blocks for organic synthesis and of significant importance for industrial applications. A great variety of synthetic methods have been developed, and quite a number of them use aldehydes as precursors. Herein
Yitao Duan, Peiyuan Yao, Yuncheng Du, Jinhui Feng, Qiaqing Wu, Dunming Zhu   +5 more
doaj   +1 more source

The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12®

Microorganisms, 2014
This review presents selected data on the probiotic strain Bifidobacterium animalis subsp. lactis BB-12® (BB-12®), which is the world’s most documented probiotic Bifidobacterium.
Mikkel Jungersen, Anette Wind, Eric Johansen, Jeffrey E. Christensen, Birgitte Stuer-Lauridsen, Dorte Eskesen   +5 more
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source